A modelling study to dissect the potential role of voltage-gated ion channels in activity-dependent conduction velocity changes as identified in small fiber neuropathy patients

A modelling study to dissect the potential role of voltage-gated ion channels in activity-dependent conduction velocity changes as identified in small fiber neuropathy patients

ObjectivePatients with small fiber neuropathy (SFN) suffer from neuropathic pain, which is still a therapeutic problem. Changed activation patterns of mechano-insensitive peripheral nerve fibers (CMi) could cause neuropathic pain. However, there is sparse knowledge about mechanisms leading to CMi dy...

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Bibliographic Details
Main Authors: Anna Maxion, Ekaterina Kutafina, Maike F. Dohrn, Pierre Sacré, Angelika Lampert, Jenny Tigerholm, Barbara Namer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Computational Neuroscience
Subjects:
neuron
simulation
C-fiber axon
neuropathic pain
microneurography
voltage-gated ion channels
Online Access:https://www.frontiersin.org/articles/10.3389/fncom.2023.1265958/full

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