Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharide
It is known that lipopolysaccharide-induced endotoxemia promotes male sterility. This research project intended to examine the repercussions of nano-zinc oxide on caspase-3 and sex competence in male quail lipopolysaccharide-exposed cells. The quail were distributed at randomization into four groups...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2024-01-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.vetmedmosul.com/article_181546_8266a62c821608cba6d8ec1b02fbb37e.pdf |
| _version_ | 1797370998025093120 |
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| author | Hiyam N. Maty Hadeel M. Hameed Ashwaq A. Hassan |
| author_facet | Hiyam N. Maty Hadeel M. Hameed Ashwaq A. Hassan |
| author_sort | Hiyam N. Maty |
| collection | DOAJ |
| description | It is known that lipopolysaccharide-induced endotoxemia promotes male sterility. This research project intended to examine the repercussions of nano-zinc oxide on caspase-3 and sex competence in male quail lipopolysaccharide-exposed cells. The quail were distributed at randomization into four groups; the first collection of birds was allowed to receive the usual feed and was used as a control, while the second collection was injected intraperitoneally LPS twice weekly at a prescribed dosage of 1 mg/kg body weight, the third collection was given nano-zinc oxide at a prescribed dosage of 40 mg/kg fodder for six weeks. The four-group collection was treated with the same nano zinc oxide particle dose and injected LPS at the same decided dose. The result indicates that management of the LPS effect significantly drops in testosterone, live sperm, sperm count, testis morphometric, and Johnsen's scoring, accompanied by a rise in dead, abnormal sperm and caspase-3 as linked with control. The application of NZO 40 mg/kg diet exhibited a higher significance in testosterone and live sperm with testicular criteria and Johnsen's scoring with drop dead, abnormal sperms, and caspase-3. Treated with nano-zinc oxide concurrently with LPS causes a rise in testosterone and Johnsen's scoring with a decrease in caspase-3 comparable to the LPS group and returns the value of testosterone hormone to normal value. It concluded that supplementation of nano zinc oxide is necessary to overcome the contamination with LPS, which negatively affects male sex characteristics, and nano zinc repairs that effect. |
| first_indexed | 2024-03-08T18:13:29Z |
| format | Article |
| id | doaj.art-33285590c7084a7ca75718c8083eb940 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-03-08T18:13:29Z |
| publishDate | 2024-01-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-33285590c7084a7ca75718c8083eb9402023-12-31T20:28:51ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552024-01-0138116317110.33899/ijvs.2023.141585.3121181546Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharideHiyam N. Maty0Hadeel M. Hameed1Ashwaq A. Hassan2Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqIt is known that lipopolysaccharide-induced endotoxemia promotes male sterility. This research project intended to examine the repercussions of nano-zinc oxide on caspase-3 and sex competence in male quail lipopolysaccharide-exposed cells. The quail were distributed at randomization into four groups; the first collection of birds was allowed to receive the usual feed and was used as a control, while the second collection was injected intraperitoneally LPS twice weekly at a prescribed dosage of 1 mg/kg body weight, the third collection was given nano-zinc oxide at a prescribed dosage of 40 mg/kg fodder for six weeks. The four-group collection was treated with the same nano zinc oxide particle dose and injected LPS at the same decided dose. The result indicates that management of the LPS effect significantly drops in testosterone, live sperm, sperm count, testis morphometric, and Johnsen's scoring, accompanied by a rise in dead, abnormal sperm and caspase-3 as linked with control. The application of NZO 40 mg/kg diet exhibited a higher significance in testosterone and live sperm with testicular criteria and Johnsen's scoring with drop dead, abnormal sperms, and caspase-3. Treated with nano-zinc oxide concurrently with LPS causes a rise in testosterone and Johnsen's scoring with a decrease in caspase-3 comparable to the LPS group and returns the value of testosterone hormone to normal value. It concluded that supplementation of nano zinc oxide is necessary to overcome the contamination with LPS, which negatively affects male sex characteristics, and nano zinc repairs that effect.https://www.vetmedmosul.com/article_181546_8266a62c821608cba6d8ec1b02fbb37e.pdfapoptosisjohnsen's scoretestosteronespermatogenesis |
| spellingShingle | Hiyam N. Maty Hadeel M. Hameed Ashwaq A. Hassan Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharide Iraqi Journal of Veterinary Sciences apoptosis johnsen's score testosterone spermatogenesis |
| title | Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharide |
| title_full | Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharide |
| title_fullStr | Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharide |
| title_full_unstemmed | Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharide |
| title_short | Potency of nano-zinc oxide on caspase-3 of male quail exposed to lipopolysaccharide |
| title_sort | potency of nano zinc oxide on caspase 3 of male quail exposed to lipopolysaccharide |
| topic | apoptosis johnsen's score testosterone spermatogenesis |
| url | https://www.vetmedmosul.com/article_181546_8266a62c821608cba6d8ec1b02fbb37e.pdf |
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