Comparison and correlation of choroidal parameters in children and adolescents with different refractive status
AIM:To compare the choroidal parameters in children and adolescents with different refractive status, and to investigate the associations between ocular biometrics and choroidal parameters.METHODS:A cross sectional study. A total of 121 healthy children and adolescents(121 right eyes)aged 3-18 years...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-10-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2022/10/202210017.pdf |
| _version_ | 1818060812600737792 |
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| author | Feng-Tao Ji Hui Wang Zhi-Min Wang Wei Dai Qin Wang Yong-Rong Li Rong-Feng Liao |
| author_facet | Feng-Tao Ji Hui Wang Zhi-Min Wang Wei Dai Qin Wang Yong-Rong Li Rong-Feng Liao |
| author_sort | Feng-Tao Ji |
| collection | DOAJ |
| description | AIM:To compare the choroidal parameters in children and adolescents with different refractive status, and to investigate the associations between ocular biometrics and choroidal parameters.METHODS:A cross sectional study. A total of 121 healthy children and adolescents(121 right eyes)aged 3-18 years treated in the Second People's Hospital of Hefei were collected. The data were divided into three groups according to spherical equivalent refraction(SER): emmetropia(-0.50<SER≤+1.75D), low myopia(-3.00<SER≤-0.50D)and moderate-to-high myopia(SER≤-3.00D). Ocular biometrics were measured by using the IOL Master. Data of the choroidal structures extracted from a 6mm sub-macular region centered on the fovea, including choroidal thickness(CT), the total choroidal area(TCA), luminal area(LA), stromal area(SA)and choroidal vascularity index(CVI)were determined by image binarization of the enhanced depth imaging-optical coherence tomography(EDI-OCT). Comparing all biology parameters among the three groups, associations among demographic factors, ocular parameters, and choroidal structures were evaluated by using multiple linear regression analysis.RESULTS:TCA, LA, SA and CT were all different among the three groups before age correction(all P<0.001), and CVI was not different(P >0.05). TCA, LA, SA, CT and CVI were found to be statistically different among the three groups after age correction(all P<0.001), and there were differences in pairwise comparisons of TCA, LA, SA and CT among the three groups(all P<0.001), which were the highest in emmetropic eyes and lowest in moderate-to-high myopic eyes, However, the CVI in pairwise comparisons among the three groups showed that only the moderate-to-high myopia group was significantly lower than the emmetropic group(P=0.014). Multiple regression analysis showed that the LA was significantly associated with SER(P=0.020), whereas CT were significantly associated with the axial length(AL)(P=0.028).CONCLUSIONS: The choroidal LA and CVI tend to decrease in children and adolescents with higher myopia, indicating that the decrease of sub-foveal choroidal blood flow may be related to the progression of myopia. |
| first_indexed | 2024-12-10T13:38:22Z |
| format | Article |
| id | doaj.art-332ac858fe6d404f865f471345a8a9a2 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-12-10T13:38:22Z |
| publishDate | 2022-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-332ac858fe6d404f865f471345a8a9a22022-12-22T01:46:46ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-10-0122101682168610.3980/j.issn.1672-5123.2022.10.17202210017Comparison and correlation of choroidal parameters in children and adolescents with different refractive statusFeng-Tao Ji0Hui Wang1Zhi-Min Wang2Wei Dai3Qin Wang4Yong-Rong Li5Rong-Feng Liao6Department of Ophthalmology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China; the Second People's Hospital of Hefei;Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, Chinathe Second People's Hospital of Hefei;Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, Chinathe Second People's Hospital of Hefei;Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, Chinathe Second People's Hospital of Hefei;Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, Chinathe Second People's Hospital of Hefei;Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, Chinathe Second People's Hospital of Hefei;Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, ChinaAIM:To compare the choroidal parameters in children and adolescents with different refractive status, and to investigate the associations between ocular biometrics and choroidal parameters.METHODS:A cross sectional study. A total of 121 healthy children and adolescents(121 right eyes)aged 3-18 years treated in the Second People's Hospital of Hefei were collected. The data were divided into three groups according to spherical equivalent refraction(SER): emmetropia(-0.50<SER≤+1.75D), low myopia(-3.00<SER≤-0.50D)and moderate-to-high myopia(SER≤-3.00D). Ocular biometrics were measured by using the IOL Master. Data of the choroidal structures extracted from a 6mm sub-macular region centered on the fovea, including choroidal thickness(CT), the total choroidal area(TCA), luminal area(LA), stromal area(SA)and choroidal vascularity index(CVI)were determined by image binarization of the enhanced depth imaging-optical coherence tomography(EDI-OCT). Comparing all biology parameters among the three groups, associations among demographic factors, ocular parameters, and choroidal structures were evaluated by using multiple linear regression analysis.RESULTS:TCA, LA, SA and CT were all different among the three groups before age correction(all P<0.001), and CVI was not different(P >0.05). TCA, LA, SA, CT and CVI were found to be statistically different among the three groups after age correction(all P<0.001), and there were differences in pairwise comparisons of TCA, LA, SA and CT among the three groups(all P<0.001), which were the highest in emmetropic eyes and lowest in moderate-to-high myopic eyes, However, the CVI in pairwise comparisons among the three groups showed that only the moderate-to-high myopia group was significantly lower than the emmetropic group(P=0.014). Multiple regression analysis showed that the LA was significantly associated with SER(P=0.020), whereas CT were significantly associated with the axial length(AL)(P=0.028).CONCLUSIONS: The choroidal LA and CVI tend to decrease in children and adolescents with higher myopia, indicating that the decrease of sub-foveal choroidal blood flow may be related to the progression of myopia.http://ies.ijo.cn/cn_publish/2022/10/202210017.pdfmyopiachildren and adolescentschoroidal vascularity indexbinarizationenhanced depth imaging-optical coherence tomography |
| spellingShingle | Feng-Tao Ji Hui Wang Zhi-Min Wang Wei Dai Qin Wang Yong-Rong Li Rong-Feng Liao Comparison and correlation of choroidal parameters in children and adolescents with different refractive status Guoji Yanke Zazhi myopia children and adolescents choroidal vascularity index binarization enhanced depth imaging-optical coherence tomography |
| title | Comparison and correlation of choroidal parameters in children and adolescents with different refractive status |
| title_full | Comparison and correlation of choroidal parameters in children and adolescents with different refractive status |
| title_fullStr | Comparison and correlation of choroidal parameters in children and adolescents with different refractive status |
| title_full_unstemmed | Comparison and correlation of choroidal parameters in children and adolescents with different refractive status |
| title_short | Comparison and correlation of choroidal parameters in children and adolescents with different refractive status |
| title_sort | comparison and correlation of choroidal parameters in children and adolescents with different refractive status |
| topic | myopia children and adolescents choroidal vascularity index binarization enhanced depth imaging-optical coherence tomography |
| url | http://ies.ijo.cn/cn_publish/2022/10/202210017.pdf |
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