Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery
Background: The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, marks a step forward the future diagnostic approach to these neoplasms. Alongside this, radiomics has experienced rapid evolution over the last several years, allowing us to corr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/940 |
| _version_ | 1797624949885632512 |
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| author | Rosa Maria Gerardi Roberto Cannella Lapo Bonosi Federica Vernuccio Gianluca Ferini Anna Viola Valentina Zagardo Felice Buscemi Roberta Costanzo Massimiliano Porzio Evier Andrea Giovannini Federica Paolini Lara Brunasso Giuseppe Roberto Giammalva Giuseppe Emmanuele Umana Antonino Scarpitta Domenico Gerardo Iacopino Rosario Maugeri |
| author_facet | Rosa Maria Gerardi Roberto Cannella Lapo Bonosi Federica Vernuccio Gianluca Ferini Anna Viola Valentina Zagardo Felice Buscemi Roberta Costanzo Massimiliano Porzio Evier Andrea Giovannini Federica Paolini Lara Brunasso Giuseppe Roberto Giammalva Giuseppe Emmanuele Umana Antonino Scarpitta Domenico Gerardo Iacopino Rosario Maugeri |
| author_sort | Rosa Maria Gerardi |
| collection | DOAJ |
| description | Background: The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, marks a step forward the future diagnostic approach to these neoplasms. Alongside this, radiomics has experienced rapid evolution over the last several years, allowing us to correlate tumor imaging heterogeneity with a wide range of tumor molecular and subcellular features. Radiomics is a translational field focused on decoding conventional imaging data to extrapolate the molecular and prognostic features of tumors such as gliomas. We herein analyze the state-of-the-art of radiomics applied to glioblastoma, with the goal to estimate its current clinical impact and potential perspectives in relation to well-rounded patient management, including the end-of-life stage. Methods: A literature review was performed on the PubMed, MEDLINE and Scopus databases using the following search items: “radiomics and glioma”, “radiomics and glioblastoma”, “radiomics and glioma and IDH”, “radiomics and glioma and TERT promoter”, “radiomics and glioma and EGFR”, “radiomics and glioma and chromosome”. Results: A total of 719 articles were screened. Further quantitative and qualitative analysis allowed us to finally include 11 papers. This analysis shows that radiomics is rapidly evolving towards a reliable tool. Conclusions: Further studies are necessary to adjust radiomics’ potential to the newest molecular requirements pointed out by the 2021 WHO classification of CNS tumors. At a glance, its application in the clinical routine could be beneficial to achieve a timely diagnosis, especially for those patients not eligible for surgery and/or adjuvant therapies but still deserving palliative and supportive care. |
| first_indexed | 2024-03-11T09:49:54Z |
| format | Article |
| id | doaj.art-332b949489b6426999ba722f10a88c40 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:49:54Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-332b949489b6426999ba722f10a88c402023-11-16T16:19:25ZengMDPI AGCancers2072-66942023-02-0115394010.3390/cancers15030940Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to NeurosurgeryRosa Maria Gerardi0Roberto Cannella1Lapo Bonosi2Federica Vernuccio3Gianluca Ferini4Anna Viola5Valentina Zagardo6Felice Buscemi7Roberta Costanzo8Massimiliano Porzio9Evier Andrea Giovannini10Federica Paolini11Lara Brunasso12Giuseppe Roberto Giammalva13Giuseppe Emmanuele Umana14Antonino Scarpitta15Domenico Gerardo Iacopino16Rosario Maugeri17Neurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalySection of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyInstitute of Radiology, DIMED, University Hospital of Padova, 35121 Padova, ItalyDepartment of Radiation Oncology, REM Radioterapia srl, 95029 Vaigrande, ItalyDepartment of Radiation Oncology, REM Radioterapia srl, 95029 Vaigrande, ItalyDepartment of Radiation Oncology, REM Radioterapia srl, 95029 Vaigrande, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalySection of Radiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, ItalyNeurology Unit, ASP Trapani, 91026 Mazara del Vallo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyBackground: The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, marks a step forward the future diagnostic approach to these neoplasms. Alongside this, radiomics has experienced rapid evolution over the last several years, allowing us to correlate tumor imaging heterogeneity with a wide range of tumor molecular and subcellular features. Radiomics is a translational field focused on decoding conventional imaging data to extrapolate the molecular and prognostic features of tumors such as gliomas. We herein analyze the state-of-the-art of radiomics applied to glioblastoma, with the goal to estimate its current clinical impact and potential perspectives in relation to well-rounded patient management, including the end-of-life stage. Methods: A literature review was performed on the PubMed, MEDLINE and Scopus databases using the following search items: “radiomics and glioma”, “radiomics and glioblastoma”, “radiomics and glioma and IDH”, “radiomics and glioma and TERT promoter”, “radiomics and glioma and EGFR”, “radiomics and glioma and chromosome”. Results: A total of 719 articles were screened. Further quantitative and qualitative analysis allowed us to finally include 11 papers. This analysis shows that radiomics is rapidly evolving towards a reliable tool. Conclusions: Further studies are necessary to adjust radiomics’ potential to the newest molecular requirements pointed out by the 2021 WHO classification of CNS tumors. At a glance, its application in the clinical routine could be beneficial to achieve a timely diagnosis, especially for those patients not eligible for surgery and/or adjuvant therapies but still deserving palliative and supportive care.https://www.mdpi.com/2072-6694/15/3/940glioblastomabrain tumorWHO classificationTERTpEGFRIDH |
| spellingShingle | Rosa Maria Gerardi Roberto Cannella Lapo Bonosi Federica Vernuccio Gianluca Ferini Anna Viola Valentina Zagardo Felice Buscemi Roberta Costanzo Massimiliano Porzio Evier Andrea Giovannini Federica Paolini Lara Brunasso Giuseppe Roberto Giammalva Giuseppe Emmanuele Umana Antonino Scarpitta Domenico Gerardo Iacopino Rosario Maugeri Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery Cancers glioblastoma brain tumor WHO classification TERTp EGFR IDH |
| title | Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery |
| title_full | Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery |
| title_fullStr | Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery |
| title_full_unstemmed | Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery |
| title_short | Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery |
| title_sort | forecasting molecular features in idh wildtype gliomas the state of the art of radiomics applied to neurosurgery |
| topic | glioblastoma brain tumor WHO classification TERTp EGFR IDH |
| url | https://www.mdpi.com/2072-6694/15/3/940 |
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