Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life study
Abstract Purpose To describe real-life data from wet age-related macular degeneration (AMD) patients treated with anti-vascular endothelial growth factors (VEGFs) and to compare our results with previous studies and clinical trials. Methods This retrospective monocentric cohort study analyzed 865 ey...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-08-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-021-02055-6 |
| _version_ | 1819137056484360192 |
|---|---|
| author | Paolo Corazza Francesco Maria D’Alterio Jamil Kabbani Mostafa Mohamed Ragheb Alam Stefano Mercuri Harry Otway Orlans Saad Younis |
| author_facet | Paolo Corazza Francesco Maria D’Alterio Jamil Kabbani Mostafa Mohamed Ragheb Alam Stefano Mercuri Harry Otway Orlans Saad Younis |
| author_sort | Paolo Corazza |
| collection | DOAJ |
| description | Abstract Purpose To describe real-life data from wet age-related macular degeneration (AMD) patients treated with anti-vascular endothelial growth factors (VEGFs) and to compare our results with previous studies and clinical trials. Methods This retrospective monocentric cohort study analyzed 865 eyes of 780 wet-AMD patients treated with an anti-VEGF treat-and-extend regimen over a long-term follow-up period. Aflibercept and Ranibizumab were considered first-line agents whereas Bevacizumab was reserved for use on a compassionate basis in patients not meeting treatment criteria. All patients underwent a best corrected visual acuity (BCVA) assessment at each follow-up visit. Results One-year follow-up figures were available for 82.5% of patients, whilst follow-up data was recorded for 55.6%, 37.6%, 25.1%, and 15.0% of the cohort at years 2, 3, 4, and 5 respectively. Patients treated with Bevacizumab received fewer yearly injections than those treated with Ranibizumab. However, no significant difference in the number of injections per year was detected in other comparisons between groups. Whilst our data showed no significant difference in mean BCVA between the three groups, there was a gradual deterioration of visual function over time for the patient cohort as a whole. Conclusion No significant differences between the 3 anti-VEGF molecules were recorded in wet-AMD patients in real-life conditions. Despite the long-term therapy, we found a slight reduction in visual function especially after the third year of treatment. |
| first_indexed | 2024-12-22T10:44:48Z |
| format | Article |
| id | doaj.art-332c50bb908142f98f94e1d64735627d |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-22T10:44:48Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-332c50bb908142f98f94e1d64735627d2022-12-21T18:28:58ZengBMCBMC Ophthalmology1471-24152021-08-012111810.1186/s12886-021-02055-6Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life studyPaolo Corazza0Francesco Maria D’Alterio1Jamil Kabbani2Mostafa Mohamed Ragheb Alam3Stefano Mercuri4Harry Otway Orlans5Saad Younis6Western Eye Hospital, Imperial College Healthcare NHS TrustWestern Eye Hospital, Imperial College Healthcare NHS TrustImperial CollegeWestern Eye Hospital, Imperial College Healthcare NHS TrustWestern Eye Hospital, Imperial College Healthcare NHS TrustWestern Eye Hospital, Imperial College Healthcare NHS TrustWestern Eye Hospital, Imperial College Healthcare NHS TrustAbstract Purpose To describe real-life data from wet age-related macular degeneration (AMD) patients treated with anti-vascular endothelial growth factors (VEGFs) and to compare our results with previous studies and clinical trials. Methods This retrospective monocentric cohort study analyzed 865 eyes of 780 wet-AMD patients treated with an anti-VEGF treat-and-extend regimen over a long-term follow-up period. Aflibercept and Ranibizumab were considered first-line agents whereas Bevacizumab was reserved for use on a compassionate basis in patients not meeting treatment criteria. All patients underwent a best corrected visual acuity (BCVA) assessment at each follow-up visit. Results One-year follow-up figures were available for 82.5% of patients, whilst follow-up data was recorded for 55.6%, 37.6%, 25.1%, and 15.0% of the cohort at years 2, 3, 4, and 5 respectively. Patients treated with Bevacizumab received fewer yearly injections than those treated with Ranibizumab. However, no significant difference in the number of injections per year was detected in other comparisons between groups. Whilst our data showed no significant difference in mean BCVA between the three groups, there was a gradual deterioration of visual function over time for the patient cohort as a whole. Conclusion No significant differences between the 3 anti-VEGF molecules were recorded in wet-AMD patients in real-life conditions. Despite the long-term therapy, we found a slight reduction in visual function especially after the third year of treatment.https://doi.org/10.1186/s12886-021-02055-6Anti-VEGF therapyChoroidal neovascularizationTreat and extendWet-AMDReal life dataIntravitreal injections |
| spellingShingle | Paolo Corazza Francesco Maria D’Alterio Jamil Kabbani Mostafa Mohamed Ragheb Alam Stefano Mercuri Harry Otway Orlans Saad Younis Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life study BMC Ophthalmology Anti-VEGF therapy Choroidal neovascularization Treat and extend Wet-AMD Real life data Intravitreal injections |
| title | Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life study |
| title_full | Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life study |
| title_fullStr | Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life study |
| title_full_unstemmed | Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life study |
| title_short | Long-term outcomes of intravitreal anti-VEGF therapies in patients affected by neovascular age-related macular degeneration: a real-life study |
| title_sort | long term outcomes of intravitreal anti vegf therapies in patients affected by neovascular age related macular degeneration a real life study |
| topic | Anti-VEGF therapy Choroidal neovascularization Treat and extend Wet-AMD Real life data Intravitreal injections |
| url | https://doi.org/10.1186/s12886-021-02055-6 |
| work_keys_str_mv | AT paolocorazza longtermoutcomesofintravitrealantivegftherapiesinpatientsaffectedbyneovascularagerelatedmaculardegenerationareallifestudy AT francescomariadalterio longtermoutcomesofintravitrealantivegftherapiesinpatientsaffectedbyneovascularagerelatedmaculardegenerationareallifestudy AT jamilkabbani longtermoutcomesofintravitrealantivegftherapiesinpatientsaffectedbyneovascularagerelatedmaculardegenerationareallifestudy AT mostafamohamedraghebalam longtermoutcomesofintravitrealantivegftherapiesinpatientsaffectedbyneovascularagerelatedmaculardegenerationareallifestudy AT stefanomercuri longtermoutcomesofintravitrealantivegftherapiesinpatientsaffectedbyneovascularagerelatedmaculardegenerationareallifestudy AT harryotwayorlans longtermoutcomesofintravitrealantivegftherapiesinpatientsaffectedbyneovascularagerelatedmaculardegenerationareallifestudy AT saadyounis longtermoutcomesofintravitrealantivegftherapiesinpatientsaffectedbyneovascularagerelatedmaculardegenerationareallifestudy |