Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex.
Infection with helminths can modulate the host immune response, which ultimately shape morbidity and mortality of the associated diseases. We studied key cytokines for essential immune response in sera from 229 southeastern China individuals infected with Clonorchis sinensis and 60 individuals witho...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-09-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0010726 |
| _version_ | 1828172694109028352 |
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| author | Shuo Kan Qi Li Hong-Mei Li Yan-Hua Yao Xin-Yue Du Chen-Yun Wu Guang-Jie Chen Xiao-Kui Guo Men-Bao Qian Zhao-Jun Wang |
| author_facet | Shuo Kan Qi Li Hong-Mei Li Yan-Hua Yao Xin-Yue Du Chen-Yun Wu Guang-Jie Chen Xiao-Kui Guo Men-Bao Qian Zhao-Jun Wang |
| author_sort | Shuo Kan |
| collection | DOAJ |
| description | Infection with helminths can modulate the host immune response, which ultimately shape morbidity and mortality of the associated diseases. We studied key cytokines for essential immune response in sera from 229 southeastern China individuals infected with Clonorchis sinensis and 60 individuals without C. sinensis infection, and measured serum specific IgG and IgE against worms in these people. Individuals infected with C. sinensis had significantly higher antigen-specific IgG and IgE levels, which were positively correlated with egg counts in feces. However, less enhancement of IgE antibody was observed in females when compared to males with similar infection levels. C. sinensis infection caused diminished Th1 cytokines (IL-1β, IL-2, IL-12p70, IFN-γ and TNF-α), Th2 cytokine (IL-4), as well as Th17 cytokine (IL-17A) in sera, which showed decreasing trend by infection intensity. Notably, these phenotypes were more significant in females than those in males. Although C. sinensis infection is associated with the development of hepatobiliary diseases, there was no significant correlation between the dampened cytokine profiles and the hepatobiliary morbidities. Our study indicates C. sinensis infection is strongly related to the immune suppression in human. Sex differences shape the immune milieus of clonorchiasis. This study provides a better understanding of how worms affect immune responses and cause a long-term immune alternation in humans with C. sinensis infection. |
| first_indexed | 2024-04-12T03:43:59Z |
| format | Article |
| id | doaj.art-332cb609a3b7439db883a630661beb91 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-12T03:43:59Z |
| publishDate | 2022-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-332cb609a3b7439db883a630661beb912022-12-22T03:49:11ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352022-09-01169e001072610.1371/journal.pntd.0010726Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex.Shuo KanQi LiHong-Mei LiYan-Hua YaoXin-Yue DuChen-Yun WuGuang-Jie ChenXiao-Kui GuoMen-Bao QianZhao-Jun WangInfection with helminths can modulate the host immune response, which ultimately shape morbidity and mortality of the associated diseases. We studied key cytokines for essential immune response in sera from 229 southeastern China individuals infected with Clonorchis sinensis and 60 individuals without C. sinensis infection, and measured serum specific IgG and IgE against worms in these people. Individuals infected with C. sinensis had significantly higher antigen-specific IgG and IgE levels, which were positively correlated with egg counts in feces. However, less enhancement of IgE antibody was observed in females when compared to males with similar infection levels. C. sinensis infection caused diminished Th1 cytokines (IL-1β, IL-2, IL-12p70, IFN-γ and TNF-α), Th2 cytokine (IL-4), as well as Th17 cytokine (IL-17A) in sera, which showed decreasing trend by infection intensity. Notably, these phenotypes were more significant in females than those in males. Although C. sinensis infection is associated with the development of hepatobiliary diseases, there was no significant correlation between the dampened cytokine profiles and the hepatobiliary morbidities. Our study indicates C. sinensis infection is strongly related to the immune suppression in human. Sex differences shape the immune milieus of clonorchiasis. This study provides a better understanding of how worms affect immune responses and cause a long-term immune alternation in humans with C. sinensis infection.https://doi.org/10.1371/journal.pntd.0010726 |
| spellingShingle | Shuo Kan Qi Li Hong-Mei Li Yan-Hua Yao Xin-Yue Du Chen-Yun Wu Guang-Jie Chen Xiao-Kui Guo Men-Bao Qian Zhao-Jun Wang Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. PLoS Neglected Tropical Diseases |
| title | Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. |
| title_full | Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. |
| title_fullStr | Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. |
| title_full_unstemmed | Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. |
| title_short | Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex. |
| title_sort | clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex |
| url | https://doi.org/10.1371/journal.pntd.0010726 |
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