Survival Effect of Complete Multimodal Therapy in Malignant Pleural Mesothelioma
Background: Malignant pleural mesothelioma (MPM) is an aggressive pleural malignancy, and despite all multimodal treatment modalities, the 5-year overall survival rate of patients with MPM is less than 20%. In the present study, we aimed to analyze the surgical and prognostic outcomes of patients...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Thoracic & Cardiovascular Surgery
2022-10-01
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| Series: | Journal of Chest Surgery |
| Subjects: |
| Summary: | Background: Malignant pleural mesothelioma (MPM) is an aggressive pleural malignancy,
and despite all multimodal treatment modalities, the 5-year overall survival rate of
patients with MPM is less than 20%. In the present study, we aimed to analyze the surgical
and prognostic outcomes of patients with MPM who received multimodal treatment.
Methods: In this retrospective, single-center study, the records of patients who underwent
surgery for MPM between January 2010 and December 2020 at our department
were reviewed retrospectively.
Results: Sixty-four patients were included in the study, of whom 23 (35.9%) were women
and 41 (64.1%) were men. Extrapleural pneumonectomy, pleurectomy/decortication,
and extended pleurectomy/decortication procedures were performed in 34.4%, 45.3%,
and 20.3% of patients, respectively. The median survival of patients was 21 months, and
the 5-year survival rate was 20.2%. Advanced tumor stage (hazard ratio [HR], 1.8; p=0.04),
right-sided extrapleural pneumonectomy (HR, 3.1; p=0.02), lymph node metastasis (HR,
1.8; p=0.04), and incomplete multimodal therapy (HR, 1.9; p=0.03) were poor prognostic
factors. There was no significant survival difference according to surgical type or histopathological
subtype.
Conclusion: Multimodal therapy can offer an acceptable survival rate in patients with
MPM. Despite its poor reputation in the literature, the survival rate after extrapleural pneumonectomy,
especially left-sided, was not as poor as might be expected. |
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| ISSN: | 2765-1606 2765-1614 |