The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonism
Abstract Introduction The widespread use of brain magnetic resonance imaging (MRI) has revealed the correlation between enlarged perivascular spaces (EPVS) and cognitive impairment (CI). However, few studies have examined the correlation between MRI-visible EPVS and CI in patients with Parkinson’s d...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-02819-7 |
| _version_ | 1818502652414132224 |
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| author | Yu Tu Wenyan Zhuo Jiewei Peng Rong Huang Baizhu Li Yuqi Liu Chengtao Zhang Xiuli Zeng Li’an Huang |
| author_facet | Yu Tu Wenyan Zhuo Jiewei Peng Rong Huang Baizhu Li Yuqi Liu Chengtao Zhang Xiuli Zeng Li’an Huang |
| author_sort | Yu Tu |
| collection | DOAJ |
| description | Abstract Introduction The widespread use of brain magnetic resonance imaging (MRI) has revealed the correlation between enlarged perivascular spaces (EPVS) and cognitive impairment (CI). However, few studies have examined the correlation between MRI-visible EPVS and CI in patients with Parkinson’s disease (PD) and vascular parkinsonism (VaP). This study explored how the number and main location of EPVS in PD and VaP are correlated with the occurrence of CI in these diseases to provide radiology markers and other evidence for early clinical diagnosis in a Chinese cohort. Methods Clinical data were prospectively collected from 77 patients: 26 patients clinically diagnosed with PD or probable PD, 19 patients clinically diagnosed with VaP, and 32 control subjects with normal cognitive function and no stroke or parkinsonism. The patients with PD and VaP were divided into a CI group and a no CI (NCI) group according to the Montreal Cognitive Assessment Beijing version (MoCA-BJ). The relevant clinical data were statistically analysed. Results The centrum semiovale (CSO)-EPVS, lacunes, Fazekas scores, global cortical atrophy scale (GCA) scores, Koedam posterior atrophy visual scale (KS) scores, and medial temporal atrophy (MTA) scores were higher in the PD-CI and VaP-CI groups than in the control group (adjusted P < 0.017). The number of basal ganglia (BG)-EPVS in the VaP group was higher than that in the PD and control groups (adjusted P < 0.017). BG-EPVS, Fazekas scores, GCA scores, KS scores, and MTA scores were higher in the VaP-CI group than in the PD-CI group (adjusted P < 0.017). Multivariate logistic regression analysis showed that the differences in BG-EPVS and Fazekas scores were not significant between PD-CI and VaP-CI patients (P > 0.05). Conclusion VaP-CI results from multiple factors and is significantly associated with BG-EPVS, lacunes, white matter hyperintensities and brain atrophy. BG-EPVS can be used as an imaging marker to distinguish VaP-CI from PD-CI. |
| first_indexed | 2024-12-10T21:13:06Z |
| format | Article |
| id | doaj.art-332f636e4a6c4a8ea28d1ae4dcfc26c9 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-10T21:13:06Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
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| series | BMC Neurology |
| spelling | doaj.art-332f636e4a6c4a8ea28d1ae4dcfc26c92022-12-22T01:33:24ZengBMCBMC Neurology1471-23772022-07-012211910.1186/s12883-022-02819-7The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonismYu Tu0Wenyan Zhuo1Jiewei Peng2Rong Huang3Baizhu Li4Yuqi Liu5Chengtao Zhang6Xiuli Zeng7Li’an Huang8Department of Neurology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University)Department of Neurology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University)Department of Neurology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University)Department of Neurology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University)Department of Neurology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University)Department of Neurology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University)Department of Neurology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University)Department of Neurology, The First Affiliated Hospital, Jinan UniversityDepartment of Neurology, The First Affiliated Hospital, Jinan UniversityAbstract Introduction The widespread use of brain magnetic resonance imaging (MRI) has revealed the correlation between enlarged perivascular spaces (EPVS) and cognitive impairment (CI). However, few studies have examined the correlation between MRI-visible EPVS and CI in patients with Parkinson’s disease (PD) and vascular parkinsonism (VaP). This study explored how the number and main location of EPVS in PD and VaP are correlated with the occurrence of CI in these diseases to provide radiology markers and other evidence for early clinical diagnosis in a Chinese cohort. Methods Clinical data were prospectively collected from 77 patients: 26 patients clinically diagnosed with PD or probable PD, 19 patients clinically diagnosed with VaP, and 32 control subjects with normal cognitive function and no stroke or parkinsonism. The patients with PD and VaP were divided into a CI group and a no CI (NCI) group according to the Montreal Cognitive Assessment Beijing version (MoCA-BJ). The relevant clinical data were statistically analysed. Results The centrum semiovale (CSO)-EPVS, lacunes, Fazekas scores, global cortical atrophy scale (GCA) scores, Koedam posterior atrophy visual scale (KS) scores, and medial temporal atrophy (MTA) scores were higher in the PD-CI and VaP-CI groups than in the control group (adjusted P < 0.017). The number of basal ganglia (BG)-EPVS in the VaP group was higher than that in the PD and control groups (adjusted P < 0.017). BG-EPVS, Fazekas scores, GCA scores, KS scores, and MTA scores were higher in the VaP-CI group than in the PD-CI group (adjusted P < 0.017). Multivariate logistic regression analysis showed that the differences in BG-EPVS and Fazekas scores were not significant between PD-CI and VaP-CI patients (P > 0.05). Conclusion VaP-CI results from multiple factors and is significantly associated with BG-EPVS, lacunes, white matter hyperintensities and brain atrophy. BG-EPVS can be used as an imaging marker to distinguish VaP-CI from PD-CI.https://doi.org/10.1186/s12883-022-02819-7Enlarged perivascular spacesVascular parkinsonismParkinson’s diseaseCognitive impairmentWhite matter hyperintensity |
| spellingShingle | Yu Tu Wenyan Zhuo Jiewei Peng Rong Huang Baizhu Li Yuqi Liu Chengtao Zhang Xiuli Zeng Li’an Huang The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonism BMC Neurology Enlarged perivascular spaces Vascular parkinsonism Parkinson’s disease Cognitive impairment White matter hyperintensity |
| title | The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonism |
| title_full | The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonism |
| title_fullStr | The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonism |
| title_full_unstemmed | The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonism |
| title_short | The correlation between enlarged perivascular spaces and cognitive impairment in Parkinson’s disease and vascular parkinsonism |
| title_sort | correlation between enlarged perivascular spaces and cognitive impairment in parkinson s disease and vascular parkinsonism |
| topic | Enlarged perivascular spaces Vascular parkinsonism Parkinson’s disease Cognitive impairment White matter hyperintensity |
| url | https://doi.org/10.1186/s12883-022-02819-7 |
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