The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected Patients
We aimed to investigate the association of pretreatment host and/or viral related factors with sustained virological response (SVR) rate in chronic hepatitis C (CHC) infected patients. This cohort study was performed on 200 IFN-naïve Iranian CHC patients who were treated with pegylated interferon-α...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2020-08-01
|
| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8217 |
| _version_ | 1818206746613645312 |
|---|---|
| author | Javad Moayedi Tayebeh Hashempour Zahra Musavi Behzad Dehghani Zahra Hasanshahi Shahin Merat |
| author_facet | Javad Moayedi Tayebeh Hashempour Zahra Musavi Behzad Dehghani Zahra Hasanshahi Shahin Merat |
| author_sort | Javad Moayedi |
| collection | DOAJ |
| description | We aimed to investigate the association of pretreatment host and/or viral related factors with sustained virological response (SVR) rate in chronic hepatitis C (CHC) infected patients. This cohort study was performed on 200 IFN-naïve Iranian CHC patients who were treated with pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV). Pretreatment levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting blood sugar (FBS), HCV load and genotype were determined, and the pattern of changes was monitored throughout the course of treatment. The baseline FBS value in the non-responder group was significantly higher than that of the SVR group. The SVR group showed a rapid and continuous decline of ALT/AST activity from the beginning of the treatment, while the ALT level was fluctuating in non-responder and relapse groups. Persistent normalization of transaminases during combination antiviral therapy was significantly associated with SVR rate. Besides, age and FBS levels had the greatest impact on SVR. Minocycline seems to be a safe and effective adjuvant in the management of patients with schizophrenia. |
| first_indexed | 2024-12-12T04:17:56Z |
| format | Article |
| id | doaj.art-3330bd0748264164a1c3b60fd17fc220 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-12T04:17:56Z |
| publishDate | 2020-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-3330bd0748264164a1c3b60fd17fc2202022-12-22T00:38:23ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942020-08-0158510.18502/acta.v58i5.3954The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected PatientsJavad Moayedi0Tayebeh Hashempour1Zahra Musavi2Behzad Dehghani3Zahra Hasanshahi4Shahin Merat5Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranShiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranShiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranShiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranShiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranLiver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.We aimed to investigate the association of pretreatment host and/or viral related factors with sustained virological response (SVR) rate in chronic hepatitis C (CHC) infected patients. This cohort study was performed on 200 IFN-naïve Iranian CHC patients who were treated with pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV). Pretreatment levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting blood sugar (FBS), HCV load and genotype were determined, and the pattern of changes was monitored throughout the course of treatment. The baseline FBS value in the non-responder group was significantly higher than that of the SVR group. The SVR group showed a rapid and continuous decline of ALT/AST activity from the beginning of the treatment, while the ALT level was fluctuating in non-responder and relapse groups. Persistent normalization of transaminases during combination antiviral therapy was significantly associated with SVR rate. Besides, age and FBS levels had the greatest impact on SVR. Minocycline seems to be a safe and effective adjuvant in the management of patients with schizophrenia.https://acta.tums.ac.ir/index.php/acta/article/view/8217Hepatitis C virus (HCV)Sustained virological responsePredictive marker |
| spellingShingle | Javad Moayedi Tayebeh Hashempour Zahra Musavi Behzad Dehghani Zahra Hasanshahi Shahin Merat The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected Patients Acta Medica Iranica Hepatitis C virus (HCV) Sustained virological response Predictive marker |
| title | The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected Patients |
| title_full | The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected Patients |
| title_fullStr | The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected Patients |
| title_full_unstemmed | The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected Patients |
| title_short | The Predictive Factors for Favorable Outcomes of Peginterferon and Ribavirin Combination Therapy in HCV-Infected Patients |
| title_sort | predictive factors for favorable outcomes of peginterferon and ribavirin combination therapy in hcv infected patients |
| topic | Hepatitis C virus (HCV) Sustained virological response Predictive marker |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/8217 |
| work_keys_str_mv | AT javadmoayedi thepredictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT tayebehhashempour thepredictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT zahramusavi thepredictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT behzaddehghani thepredictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT zahrahasanshahi thepredictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT shahinmerat thepredictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT javadmoayedi predictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT tayebehhashempour predictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT zahramusavi predictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT behzaddehghani predictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT zahrahasanshahi predictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients AT shahinmerat predictivefactorsforfavorableoutcomesofpeginterferonandribavirincombinationtherapyinhcvinfectedpatients |