THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS
Iron overload in patients with thalassemia major (TM) affects glucose regulation, and is mediated by several mechanisms. These include the oxidative damage inflicted by iron on the pancreatic ß -cells and liver cells leading to pancreatic and hepatic dysfunction and insulin resistance. These disturb...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2660 |
| _version_ | 1826908984092655616 |
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| author | Vincenzo De Sanctis |
| author_facet | Vincenzo De Sanctis |
| author_sort | Vincenzo De Sanctis |
| collection | DOAJ |
| description | Iron overload in patients with thalassemia major (TM) affects glucose regulation, and is mediated by several mechanisms. These include the oxidative damage inflicted by iron on the pancreatic ß -cells and liver cells leading to pancreatic and hepatic dysfunction and insulin resistance. These disturbances have been identified by oral glucose tolerance test (OGTT), euglycemic insulin clamp, homeostatic model assessment (HOMA), intravenous glucose tolerance test (IVGT) and continuous glucose monitoring system (CGMS). A group of endocrinologists, hematologists and paediatricians, members of the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A) convened to formulate recommendations for the diagnosis and management of abnormalities of glucose homeostasis in thalassemia major patients on the basis of available evidence from clinical and laboratory data and consensus practice. The results of their work and discussions are described in this article.
Key words: Thalassemia major; Glucose homeostasis; Diagnosis; Management; Guidelines |
| first_indexed | 2024-12-19T23:44:04Z |
| format | Article |
| id | doaj.art-3332350980f547d4a44af00006cdfeeb |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2025-02-17T09:33:01Z |
| publishDate | 2016-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-3332350980f547d4a44af00006cdfeeb2025-01-02T10:23:24ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062016-10-0180e2016058e201605810.4084/mjhid.2016.0581647THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTSVincenzo De SanctisIron overload in patients with thalassemia major (TM) affects glucose regulation, and is mediated by several mechanisms. These include the oxidative damage inflicted by iron on the pancreatic ß -cells and liver cells leading to pancreatic and hepatic dysfunction and insulin resistance. These disturbances have been identified by oral glucose tolerance test (OGTT), euglycemic insulin clamp, homeostatic model assessment (HOMA), intravenous glucose tolerance test (IVGT) and continuous glucose monitoring system (CGMS). A group of endocrinologists, hematologists and paediatricians, members of the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A) convened to formulate recommendations for the diagnosis and management of abnormalities of glucose homeostasis in thalassemia major patients on the basis of available evidence from clinical and laboratory data and consensus practice. The results of their work and discussions are described in this article. Key words: Thalassemia major; Glucose homeostasis; Diagnosis; Management; Guidelineshttp://www.mjhid.org/index.php/mjhid/article/view/2660Thalassemia majorGlucose homeostasisDiagnosisManagementGuidelines |
| spellingShingle | Vincenzo De Sanctis THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS Mediterranean Journal of Hematology and Infectious Diseases Thalassemia major Glucose homeostasis Diagnosis Management Guidelines |
| title | THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS |
| title_full | THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS |
| title_fullStr | THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS |
| title_full_unstemmed | THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS |
| title_short | THE ICET-A RECOMMENDATIONS FOR THE DIAGNOSIS AND MANAGEMENT OF DISTURBANCES OF GLUCOSE HOMEOSTASIS IN THALASSEMIA MAJOR PATIENTS |
| title_sort | icet a recommendations for the diagnosis and management of disturbances of glucose homeostasis in thalassemia major patients |
| topic | Thalassemia major Glucose homeostasis Diagnosis Management Guidelines |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2660 |
| work_keys_str_mv | AT vincenzodesanctis theicetarecommendationsforthediagnosisandmanagementofdisturbancesofglucosehomeostasisinthalassemiamajorpatients AT vincenzodesanctis icetarecommendationsforthediagnosisandmanagementofdisturbancesofglucosehomeostasisinthalassemiamajorpatients |