Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block
Abstract For applying a genotype‐based treatment in neonatal long QT syndrome (LQTS), early detection of the genotype becomes an important issue. We report a case of a neonate with LQTS type 3 that presented with 2:1 atrioventricular block and underwent a mexiletine infusion challenge test, and achi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-08-01
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| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/joa3.12209 |
| _version_ | 1819112021821489152 |
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| author | Hajime Okuwaki Yoshiaki Kato Lisheng Lin Yoshihiro Nozaki Miho Takahashi‐Igari Hitoshi Horigome |
| author_facet | Hajime Okuwaki Yoshiaki Kato Lisheng Lin Yoshihiro Nozaki Miho Takahashi‐Igari Hitoshi Horigome |
| author_sort | Hajime Okuwaki |
| collection | DOAJ |
| description | Abstract For applying a genotype‐based treatment in neonatal long QT syndrome (LQTS), early detection of the genotype becomes an important issue. We report a case of a neonate with LQTS type 3 that presented with 2:1 atrioventricular block and underwent a mexiletine infusion challenge test, and achieved shortening of the QTc and 1:1 atrioventricular conduction. The mexiletine infusion challenge test was helpful to make an early detection of the genotype of the LQTS and predicted the drug efficacy in a neonatal patient. |
| first_indexed | 2024-12-22T04:06:53Z |
| format | Article |
| id | doaj.art-33333e5217ce4bdbb45e5a66927420ed |
| institution | Directory Open Access Journal |
| issn | 1880-4276 1883-2148 |
| language | English |
| last_indexed | 2024-12-22T04:06:53Z |
| publishDate | 2019-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-33333e5217ce4bdbb45e5a66927420ed2022-12-21T18:39:37ZengWileyJournal of Arrhythmia1880-42761883-21482019-08-0135468568810.1002/joa3.12209Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular blockHajime Okuwaki0Yoshiaki Kato1Lisheng Lin2Yoshihiro Nozaki3Miho Takahashi‐Igari4Hitoshi Horigome5Department of Child Health, Faculty of Medicine University of Tsukuba Tsukuba JapanDepartment of Child Health, Faculty of Medicine University of Tsukuba Tsukuba JapanDepartment of Child Health, Faculty of Medicine University of Tsukuba Tsukuba JapanDepartment of Child Health, Faculty of Medicine University of Tsukuba Tsukuba JapanDepartment of Child Health, Faculty of Medicine University of Tsukuba Tsukuba JapanDepartment of Child Health, Faculty of Medicine University of Tsukuba Tsukuba JapanAbstract For applying a genotype‐based treatment in neonatal long QT syndrome (LQTS), early detection of the genotype becomes an important issue. We report a case of a neonate with LQTS type 3 that presented with 2:1 atrioventricular block and underwent a mexiletine infusion challenge test, and achieved shortening of the QTc and 1:1 atrioventricular conduction. The mexiletine infusion challenge test was helpful to make an early detection of the genotype of the LQTS and predicted the drug efficacy in a neonatal patient.https://doi.org/10.1002/joa3.12209atrioventricular blocklong QT syndromemexiletineneonate |
| spellingShingle | Hajime Okuwaki Yoshiaki Kato Lisheng Lin Yoshihiro Nozaki Miho Takahashi‐Igari Hitoshi Horigome Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block Journal of Arrhythmia atrioventricular block long QT syndrome mexiletine neonate |
| title | Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block |
| title_full | Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block |
| title_fullStr | Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block |
| title_full_unstemmed | Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block |
| title_short | Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block |
| title_sort | mexiletine infusion challenge test for neonatal long qt syndrome with 2 1 atrioventricular block |
| topic | atrioventricular block long QT syndrome mexiletine neonate |
| url | https://doi.org/10.1002/joa3.12209 |
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