Metabolomic Profiling Reveals That 5-Hydroxylysine and 1-Methylnicotinamide Are Metabolic Indicators of Keloid Severity

Metabolomic Profiling Reveals That 5-Hydroxylysine and 1-Methylnicotinamide Are Metabolic Indicators of Keloid Severity

Background: Keloid is a skin fibroproliferative disease with unknown pathogenesis. Metabolomics provides a new perspective for revealing biomarkers related to metabolites and their metabolic mechanisms.Method: Metabolomics and transcriptomics were used for data analysis. Quality control of the data...

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Bibliographic Details
Main Authors: Mengjie Shan, Hao Liu, Yan Hao, Kexin Song, Tian Meng, Cheng Feng, Youbin Wang, Yongsheng Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Genetics
Subjects:
keloid
metabolomic
random forest
PLS-DA
machine learning
neural network model
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.804248/full

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