Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE»)
Objective: to study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years old. Using the methods proposed by the WHO International Program “MONICA-psychosocial” and “HAPIEE”, a representative sample of men aged 45–64 years old (n = 7...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2020-04-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/382 |
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| author | V. V. Gafarov E. A. Gromova D. O. Panov I. V. Gagulin V. N. Maksimov A. V. Gafarova |
| author_facet | V. V. Gafarov E. A. Gromova D. O. Panov I. V. Gagulin V. N. Maksimov A. V. Gafarova |
| author_sort | V. V. Gafarov |
| collection | DOAJ |
| description | Objective: to study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years old. Using the methods proposed by the WHO International Program “MONICA-psychosocial” and “HAPIEE”, a representative sample of men aged 45–64 years old (n = 781 men, average age was 56.48 ± 0.2 years) in 2003-2005. All respondents independently completed a questionnaire on hostility. From the surveyed sample, using the random number method, 156 men were selected who were genotyped for MAOA-uVNTR polymorphism. It was approved that the level of hostility in the population of men was 60.3%. It was revealed that among persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common — 50.9%. The results of building a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018). The results obtained allow us to conclude that the low-active allele of the MAOA-L gene is associated with hostility. |
| first_indexed | 2024-03-12T03:59:29Z |
| format | Article |
| id | doaj.art-33343f11132d4a11974a94cd48c73b81 |
| institution | Directory Open Access Journal |
| issn | 2313-7053 2713-055X |
| language | Russian |
| last_indexed | 2025-03-14T12:37:32Z |
| publishDate | 2020-04-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj.art-33343f11132d4a11974a94cd48c73b812025-03-02T09:12:45ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2020-04-0101394410.31363/2313-7053-2020-1-39-44333Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE»)V. V. Gafarov0E. A. Gromova1D. O. Panov2I. V. Gagulin3V. N. Maksimov4A. V. Gafarova5Institute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases EpidemiologyInstitute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases EpidemiologyInstitute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases EpidemiologyInstitute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases EpidemiologyInstitute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RASInstitute of Internal and Preventive Medicine — branch of Institute of Cytology and Genetics SB RAS; Collaborative laboratory of Cardiovascular Diseases EpidemiologyObjective: to study the association of hostility with high and low-active variants of the MAOA gene in an open population of men 45-64 years old. Using the methods proposed by the WHO International Program “MONICA-psychosocial” and “HAPIEE”, a representative sample of men aged 45–64 years old (n = 781 men, average age was 56.48 ± 0.2 years) in 2003-2005. All respondents independently completed a questionnaire on hostility. From the surveyed sample, using the random number method, 156 men were selected who were genotyped for MAOA-uVNTR polymorphism. It was approved that the level of hostility in the population of men was 60.3%. It was revealed that among persons with low-active alleles of the MAOA-L gene (allele 2 and 3) a high level of hostility was more common — 50.9%. The results of building a logistic regression model showed that the presence of low-active alleles (2; 3) of the MAOA gene increases the likelihood of hostility OR = 2,103 (95% CI 1,137-3,889, p = 0.018). The results obtained allow us to conclude that the low-active allele of the MAOA-L gene is associated with hostility.https://www.bekhterevreview.com/jour/article/view/382maoa genehostilitypopulationmen |
| spellingShingle | V. V. Gafarov E. A. Gromova D. O. Panov I. V. Gagulin V. N. Maksimov A. V. Gafarova Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE») Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева maoa gene hostility population men |
| title | Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE») |
| title_full | Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE») |
| title_fullStr | Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE») |
| title_full_unstemmed | Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE») |
| title_short | Association of MAOA-uVNTR gene polymorphism with hostility in an open population of males aged 45-64 in Russia / Siberia (international program: WHO «MONICA-psychosocial», «HAPIEE») |
| title_sort | association of maoa uvntr gene polymorphism with hostility in an open population of males aged 45 64 in russia siberia international program who monica psychosocial hapiee |
| topic | maoa gene hostility population men |
| url | https://www.bekhterevreview.com/jour/article/view/382 |
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