Complement Component C3 Binds to the A3 Domain of von Willebrand Factor

Complement Component C3 Binds to the A3 Domain of von Willebrand Factor

von Willebrand factor (VWF) is a multimeric protein composed of monomeric subunits (∼280 kD) linked by disulfide bonds. During hemostasis and thrombosis, ultralarge (UL) VWF (ULVWF) multimers initiate platelet adhesion. In vitro, human C3 binds to ULVWF multimeric strings secreted by and anchored to...

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Bibliographic Details
Main Authors:	Jennifer G. Nolasco, Leticia H. Nolasco, Qi Da, Sonya Cirlos, Zaverio M. Ruggeri, Joel L. Moake, Miguel A. Cruz
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2018-07-01
Series:	TH Open
Subjects:	complement component c3 von willebrand factor alternative complement pathway thrombosis inflammation
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1672189

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