Plasma Free Fatty Acid Concentrations as a Marker for Acute Myocardial Infarction
Background: Acute myocardial infarction carries a high mortality among cardiac patients.The discovery of the fact that certain enzymes like CPK, LDH liberated into circulation following necrosis of the myocardial cells came as boon for physicians and patients. There has been a constant search of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3566/4-%207682_E(%20_%20)_F(H)_PF1(PP)_PFA(H)_OLF_PF1(PM).pdf |
| Summary: | Background: Acute myocardial infarction carries a high mortality
among cardiac patients.The discovery of the fact that certain
enzymes like CPK, LDH liberated into circulation following
necrosis of the myocardial cells came as boon for physicians
and patients. There has been a constant search of different
parameters for the diagnosis and management of CoronaryArtery
Diseases (CAD).
Aim: The present study was undertaken to investigate a possible
relation between the changes in plasma free fatty acid (FFA)
concentration and acute myocardial infarction.
Material and Methods: Fifty cases (25 males and 25 females)
of acute myocardial infarction were selected for the present
study. All the patients were in the age group of 40-70 years. For
the control group fifty (25 male and 25 female) subjects of same
age group were selected from patient’s relatives and friends.
Plasma free fatty acid concentration was estimated by
Titrametric method of Trout et al., (1960), a modified version of
Dole (1956).
Statistical Analysis: The statistical analysis of the data of the
present study was done by using SPSS, version 14.0.1 was
used.
Results: Our study showed a significant increase in plasma
FFA in the first 24 hours of acute myocardial infarction with
subsequent normalisation on the 7th day.The difference between
the first and the seventh day was statistically significant.
Conclusion: The FFA were found raised in cases of acute
myocardial infarction.On the basis of present study, it is worth
to say that estimation of serum free fatty acid should be
done routinely at the earliest opportunity in all cases of acute
myocardial infarction. |
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| ISSN: | 2249-782X 0973-709X |