Investigating the efficacy and safety of olanzapine prophylaxis for opioid-induced nausea and vomiting (JORTC-PAL20): a study protocol for an open-label, single-arm exploratory study

Investigating the efficacy and safety of olanzapine prophylaxis for opioid-induced nausea and vomiting (JORTC-PAL20): a study protocol for an open-label, single-arm exploratory study

Introduction In opioid therapy for cancer pain, opioid-induced nausea and vomiting (OINV) occur in 20%–40% of patients during initial opioid treatment or increasing opioid doses. OINV result in failure to achieve pain relief due to poor opioid adherence. Therefore, antiemetics are used to prevent OI...

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Bibliographic Details
Main Authors: Hiroto Ishiki, Eriko Satomi, Keisuke Ariyoshi, Shunsuke Oyamada, Koji Amano, Ayaka Ishikawa, Sayaka Arakawa, Tomomi Kobayashi, Naomi Sakiyama, Kota Kihara, Akio Mizushima
Format: Article
Language:English
Published: BMJ Publishing Group 2024-02-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/2/e076575.full

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https://bmjopen.bmj.com/content/14/2/e076575.full

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