Differences in signal activation by LH and hCG are mediated by the LH/CG receptor`s extracellular hinge region

Differences in signal activation by LH and hCG are mediated by the LH/CG receptor`s extracellular hinge region

The human lutropin/choriogonadotropin receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) - secreted by the placenta, and lutropin (LH) - produced by the pituitary. They induce different signaling profiles at the LHCGR. This...

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Bibliographic Details
Main Authors: Paul eGrzesik, Annika eKreuchwig, Claudia eRutz, Jens eFurkert, Burkhard eWiesner, Ralf eSchülein, Gunnar eKleinau, Joerg eGromoll, Gerd eKrause
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Endocrinology
Subjects:
GPCR Activation
choriogonadotropin
lutropin
Lutropin receptor
Glycoprotein hormone receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00140/full

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