PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies

PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies

Signal Transducers and Activators of Transcription-3 (STAT3), a potent oncogenic transcription factor, is constitutively activated in lung cancer, but mutations in pathway genes are infrequent. Protein Tyrosine Phosphatase Receptor-T (PTPRT) is an endogenous inhibitor of STAT3 and PTPRT loss-of-func...

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Bibliographic Details
Main Authors: Malabika Sen, Audrey Kindsfather, Ludmila Danilova, Feng Zhang, Raffaele Colombo, Matthew G. LaPorte, Brenda F. Kurland, Donna M. Huryn, Peter Wipf, James G. Herman
Format: Article
Language:English
Published: Taylor & Francis Group 2020-07-01
Series:Epigenetics
Subjects:
ptprt methylation
stat3
non-small cell lung cancer
Online Access:http://dx.doi.org/10.1080/15592294.2019.1676597

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