Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway

Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway

Abstract Background Germinal matrix hemorrhage (GMH) is a common neurologic event with high morbidity and mortality in preterm infants. Spleen has been reported to play a critical role in inflammatory responses by regulating peripheral immune cells which contributes to secondary brain injury. Method...

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Bibliographic Details
Main Authors: Yiting Zhang, Yan Ding, Tai Lu, Yixin Zhang, Ningbo Xu, Devin W. McBride, Jiping Tang, John H. Zhang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
Germinal matrix hemorrhage
Biliverdin reductase-A
Toll-like receptor 4
Splenic response
Endothelial nitric oxide synthase
Online Access:http://link.springer.com/article/10.1186/s12974-018-1155-z

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