| Summary: | Introduction
There has been considerable research on the association between
smoking status and thyroid cancer risk in males, yet the findings are inconsistent.
In this study, we investigated the associations of intensity, duration, cumulative
dose, and age at start of smoking, with thyroid cancer in Chinese males.
Methods
From a 1:1 matched case–control study conducted between 2015 and
2017 in Zhejiang Province, China, 676 pairs of male subjects were included
in the analysis. The associations between smoking characteristics and thyroid
cancer were evaluated in logistic regression models by odds ratios (ORs) with
95% confidence intervals (CIs).
Results
Compared with never smokers, the former smokers were 0.096 times
(95% CI: 0.012–0.778) less likely to have thyroid cancer. The significant inverse
association was not observed in current smokers (OR=0.333; 95% CI: 0.084–
1.322). Among both former and current smokers, higher smoking intensity (>10
cigarettes/day), duration (>15 years), and cumulative dose of smoking (>10 packyears)
were significantly associated with reduced occurrence of thyroid cancer.
Conclusions
Our findings indicate that former smoking is inversely associated with
thyroid cancer occurrence in Chinese males. The reduction in the occurrence
of thyroid cancer was also confirmed for both former and current smokers with
higher smoking intensity, duration, and cumulative dose.
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