Associations of intensity, duration, cumulative dose, and age at start of smoking, with thyroid cancer in Chinese males: A hospital-based case–control study in Zhejiang Province
Introduction There has been considerable research on the association between smoking status and thyroid cancer risk in males, yet the findings are inconsistent. In this study, we investigated the associations of intensity, duration, cumulative dose, and age at start of smoking, with thyroid cancer i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2020-12-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/Associations-of-intensity-duration-cumulative-dose-and-age-at-start-of-smoking-with,130350,0,2.html |
| _version_ | 1811272858328891392 |
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| author | Meng Wang* Wei W. Gong* Feng Lu Qing F. He Ru Y. Hu Jie M. Zhong Min Yu |
| author_facet | Meng Wang* Wei W. Gong* Feng Lu Qing F. He Ru Y. Hu Jie M. Zhong Min Yu |
| author_sort | Meng Wang* |
| collection | DOAJ |
| description | Introduction
There has been considerable research on the association between
smoking status and thyroid cancer risk in males, yet the findings are inconsistent.
In this study, we investigated the associations of intensity, duration, cumulative
dose, and age at start of smoking, with thyroid cancer in Chinese males.
Methods
From a 1:1 matched case–control study conducted between 2015 and
2017 in Zhejiang Province, China, 676 pairs of male subjects were included
in the analysis. The associations between smoking characteristics and thyroid
cancer were evaluated in logistic regression models by odds ratios (ORs) with
95% confidence intervals (CIs).
Results
Compared with never smokers, the former smokers were 0.096 times
(95% CI: 0.012–0.778) less likely to have thyroid cancer. The significant inverse
association was not observed in current smokers (OR=0.333; 95% CI: 0.084–
1.322). Among both former and current smokers, higher smoking intensity (>10
cigarettes/day), duration (>15 years), and cumulative dose of smoking (>10 packyears)
were significantly associated with reduced occurrence of thyroid cancer.
Conclusions
Our findings indicate that former smoking is inversely associated with
thyroid cancer occurrence in Chinese males. The reduction in the occurrence
of thyroid cancer was also confirmed for both former and current smokers with
higher smoking intensity, duration, and cumulative dose. |
| first_indexed | 2024-04-12T22:47:46Z |
| format | Article |
| id | doaj.art-333bb710649c4d968c9919a9575a4726 |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-04-12T22:47:46Z |
| publishDate | 2020-12-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-333bb710649c4d968c9919a9575a47262022-12-22T03:13:28ZengEuropean PublishingTobacco Induced Diseases1617-96252020-12-0118December1810.18332/tid/130350130350Associations of intensity, duration, cumulative dose, and age at start of smoking, with thyroid cancer in Chinese males: A hospital-based case–control study in Zhejiang ProvinceMeng Wang*0Wei W. Gong*1Feng Lu2Qing F. He3Ru Y. Hu4Jie M. Zhong5Min Yu6Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, ChinaIntroduction There has been considerable research on the association between smoking status and thyroid cancer risk in males, yet the findings are inconsistent. In this study, we investigated the associations of intensity, duration, cumulative dose, and age at start of smoking, with thyroid cancer in Chinese males. Methods From a 1:1 matched case–control study conducted between 2015 and 2017 in Zhejiang Province, China, 676 pairs of male subjects were included in the analysis. The associations between smoking characteristics and thyroid cancer were evaluated in logistic regression models by odds ratios (ORs) with 95% confidence intervals (CIs). Results Compared with never smokers, the former smokers were 0.096 times (95% CI: 0.012–0.778) less likely to have thyroid cancer. The significant inverse association was not observed in current smokers (OR=0.333; 95% CI: 0.084– 1.322). Among both former and current smokers, higher smoking intensity (>10 cigarettes/day), duration (>15 years), and cumulative dose of smoking (>10 packyears) were significantly associated with reduced occurrence of thyroid cancer. Conclusions Our findings indicate that former smoking is inversely associated with thyroid cancer occurrence in Chinese males. The reduction in the occurrence of thyroid cancer was also confirmed for both former and current smokers with higher smoking intensity, duration, and cumulative dose.http://www.journalssystem.com/tid/Associations-of-intensity-duration-cumulative-dose-and-age-at-start-of-smoking-with,130350,0,2.htmlthyroid cancersmokingcase–control study |
| spellingShingle | Meng Wang* Wei W. Gong* Feng Lu Qing F. He Ru Y. Hu Jie M. Zhong Min Yu Associations of intensity, duration, cumulative dose, and age at start of smoking, with thyroid cancer in Chinese males: A hospital-based case–control study in Zhejiang Province Tobacco Induced Diseases thyroid cancer smoking case–control study |
| title | Associations of intensity, duration, cumulative dose, and age
at start of smoking, with thyroid cancer in Chinese males: A
hospital-based case–control study in Zhejiang Province |
| title_full | Associations of intensity, duration, cumulative dose, and age
at start of smoking, with thyroid cancer in Chinese males: A
hospital-based case–control study in Zhejiang Province |
| title_fullStr | Associations of intensity, duration, cumulative dose, and age
at start of smoking, with thyroid cancer in Chinese males: A
hospital-based case–control study in Zhejiang Province |
| title_full_unstemmed | Associations of intensity, duration, cumulative dose, and age
at start of smoking, with thyroid cancer in Chinese males: A
hospital-based case–control study in Zhejiang Province |
| title_short | Associations of intensity, duration, cumulative dose, and age
at start of smoking, with thyroid cancer in Chinese males: A
hospital-based case–control study in Zhejiang Province |
| title_sort | associations of intensity duration cumulative dose and age at start of smoking with thyroid cancer in chinese males a hospital based case control study in zhejiang province |
| topic | thyroid cancer smoking case–control study |
| url | http://www.journalssystem.com/tid/Associations-of-intensity-duration-cumulative-dose-and-age-at-start-of-smoking-with,130350,0,2.html |
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