Caveolin‐3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function

Caveolin‐3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function

Abstract Background Caveolin‐3 (Cav3) is the principal structural component of caveolae in skeletal muscle. Dominant pathogenic mutations in the Cav3 gene, such as the Limb Girdle Muscular Dystrophy‐1C (LGMD1C) P104L mutation, result in substantial loss of Cav3 and myopathic changes characterized by...

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Bibliographic Details
Main Authors: Dinesh S. Shah, Raid B. Nisr, Clare Stretton, Gabriela Krasteva‐Christ, Harinder S. Hundal
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Caveolin‐3, LGMD1C
Caveolinopathy
Mitochondria
Skeletal Muscle
Online Access:https://doi.org/10.1002/jcsm.12541

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