Mast cell–derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections

Mast cell–derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections

Invasive bacterial infections remain a major cause of human morbidity. Group B streptococcus (GBS) are Gram-positive bacteria that cause invasive infections in humans. Here, we show that factor XIIIA–deficient (FXIIIA-deficient) female mice exhibited significantly increased susceptibility to GBS inf...

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Detalles Bibliográficos
Autores principales: Adrian M. Piliponsky, Kavita Sharma, Phoenicia Quach, Alyssa Brokaw, Shayla Nguyen, Austyn Orvis, Siddhartha S. Saha, Nyssa Becker Samanas, Ravin Seepersaud, Yu Ping Tang, Emily Mackey, Gauri Bhise, Claire Gendrin, Anna Furuta, Albert J. Seo, Eric Guga, Irina Miralda, Michelle Coleman, Erin L. Sweeney, Charlotte A. Bäuml, Diana Imhof, Jessica M. Snyder, Adam J. Moeser, Lakshmi Rajagopal
Formato: Artículo
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022-10-01
Colección:The Journal of Clinical Investigation
Materias:
Cell biology
Infectious disease
Acceso en línea:https://doi.org/10.1172/JCI157999

Internet

https://doi.org/10.1172/JCI157999

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