Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability
Ischemic stroke remains a heavy burden for industrialized countries. The only causal therapy is the recanalization of occluded vessels via thrombolysis, which due to a narrow time window still can be offered only to a minority of patients. Since the majority of patients continues to exhibit neurolog...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00357/full |
| _version_ | 1818081144296439808 |
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| author | Thorsten Roland Doeppner Dirk M. Hermann |
| author_facet | Thorsten Roland Doeppner Dirk M. Hermann |
| author_sort | Thorsten Roland Doeppner |
| collection | DOAJ |
| description | Ischemic stroke remains a heavy burden for industrialized countries. The only causal therapy is the recanalization of occluded vessels via thrombolysis, which due to a narrow time window still can be offered only to a minority of patients. Since the majority of patients continues to exhibit neurological deficits even following successful thrombolysis, restorative therapies are urgently needed that promote brain remodeling and repair once stroke injury has occurred. Due to their unique properties of action, stem cell-based strategies gained increasing interest during recent years. Using various stroke models in both rodents and primates, the transplantation of stem cells, namely of bone marrow derived mesenchymal stem cells (MSCs) or neural progenitor cells (NPCs), has been shown to promote neurological recovery most likely via indirect bystander actions. In view of promising observations, clinical proof-of-concept studies are currently under way, in which effects of stem and precursor cells are evaluated in human stroke patients. In this review we summarize already published studies, which due to the broad experience in other medical contexts mostly employed bone marrow-derived MSCs by means of intravenous transplantation. With the overall number of clinical trials limited in number, only a fraction of these studies used non-treated control groups, and only single studies were adequately blinded. Despite these limitations, first promising results justify the need for more elaborate clinical trials in order to make stem cell transplantation a success for stroke treatment in the future. |
| first_indexed | 2024-12-10T19:01:32Z |
| format | Article |
| id | doaj.art-333e8bd31de84a4384170796e55c6f44 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T19:01:32Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-333e8bd31de84a4384170796e55c6f442022-12-22T01:37:00ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022014-10-01810.3389/fncel.2014.00357105404Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicabilityThorsten Roland Doeppner0Dirk M. Hermann1University of Duisburg-EssenUniversity of Duisburg-EssenIschemic stroke remains a heavy burden for industrialized countries. The only causal therapy is the recanalization of occluded vessels via thrombolysis, which due to a narrow time window still can be offered only to a minority of patients. Since the majority of patients continues to exhibit neurological deficits even following successful thrombolysis, restorative therapies are urgently needed that promote brain remodeling and repair once stroke injury has occurred. Due to their unique properties of action, stem cell-based strategies gained increasing interest during recent years. Using various stroke models in both rodents and primates, the transplantation of stem cells, namely of bone marrow derived mesenchymal stem cells (MSCs) or neural progenitor cells (NPCs), has been shown to promote neurological recovery most likely via indirect bystander actions. In view of promising observations, clinical proof-of-concept studies are currently under way, in which effects of stem and precursor cells are evaluated in human stroke patients. In this review we summarize already published studies, which due to the broad experience in other medical contexts mostly employed bone marrow-derived MSCs by means of intravenous transplantation. With the overall number of clinical trials limited in number, only a fraction of these studies used non-treated control groups, and only single studies were adequately blinded. Despite these limitations, first promising results justify the need for more elaborate clinical trials in order to make stem cell transplantation a success for stroke treatment in the future.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00357/fullMesenchymal Stem CellsStem CellsStroketrialsneural progenitor cells |
| spellingShingle | Thorsten Roland Doeppner Dirk M. Hermann Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability Frontiers in Cellular Neuroscience Mesenchymal Stem Cells Stem Cells Stroke trials neural progenitor cells |
| title | Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability |
| title_full | Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability |
| title_fullStr | Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability |
| title_full_unstemmed | Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability |
| title_short | Stem cell-based treatments against stroke: observations from human proof-of-concept studies and considerations regarding clinical applicability |
| title_sort | stem cell based treatments against stroke observations from human proof of concept studies and considerations regarding clinical applicability |
| topic | Mesenchymal Stem Cells Stem Cells Stroke trials neural progenitor cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00357/full |
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