The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
BACKGROUND AND OBJECTIVE: Laparoscopic cholecystectomy is now the gold standard for the treatment of symptomatic gallstone disease. Despite the minimally invasive nature of laparoscopy, high incidence of postoperative nausea and vomiting (PONV) remains a major cause of morbidity. The aim of the pres...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2014-11-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/browse.php?a_code=A-10-1050-3&slc_lang=en&sid=1 |
| _version_ | 1818412890603913216 |
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| author | hamidreza Hemmati raheb Ghorbani babak Hossein-Zadeh hadith Ebrahim-Zadeh saeed Shakeri |
| author_facet | hamidreza Hemmati raheb Ghorbani babak Hossein-Zadeh hadith Ebrahim-Zadeh saeed Shakeri |
| author_sort | hamidreza Hemmati |
| collection | DOAJ |
| description | BACKGROUND AND
OBJECTIVE: Laparoscopic
cholecystectomy is now the gold standard for the treatment of symptomatic
gallstone disease. Despite the minimally invasive nature of laparoscopy, high
incidence of postoperative nausea and vomiting (PONV) remains a major cause of
morbidity. The aim of the present study was to investigate the effect of single
dose of dexamethasone on PONV in patients undergoing laparoscopic
cholecystectomy.
METHODS: This clinical
trial study included 92 patients undergoing laparoscopic cholecystectomy. We
divided the patients into two groups randomly. One group received Dexamethasone
(5mg, IV) and the other group received Saline (5cc, IV) 10 minutes
before extubation. The patients were observed for any episode and severity of
nausea and vomiting or whether the patient required any anti emetic drug in the
24 hours postoperative period.
FINDINGS: Two patients in saline group excluded the
study. There were no significant differences between groups regarding to age,
gender and body mass index. Incidence of nausea in dexamethasone and saline
groups were 34.8% (16) and 47.7% (21) respectively. The difference was not
significant (RR=0.73, CI 95%: 0.44-1.20, p=0.310). Also incidence of vomiting
in dexamethasone and saline groups were 30.4% (14) and 34.1% (15) respectively,
and the difference was not significant (RR=0.89, CI 95%: 0.49-1.69, p=0.884).
CONCLUSION: Our study has shown that a single dose
dexamethasone (5mg, IV), 10 minutes before extubation, has no effect on PONV. |
| first_indexed | 2024-12-14T10:54:30Z |
| format | Article |
| id | doaj.art-33425c1c5cdf4a7b810a917a2465506b |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-14T10:54:30Z |
| publishDate | 2014-11-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-33425c1c5cdf4a7b810a917a2465506b2022-12-21T23:05:00ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702014-11-0116111521The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomyhamidreza Hemmati0raheb Ghorbani1babak Hossein-Zadeh2hadith Ebrahim-Zadeh3saeed Shakeri4 BACKGROUND AND OBJECTIVE: Laparoscopic cholecystectomy is now the gold standard for the treatment of symptomatic gallstone disease. Despite the minimally invasive nature of laparoscopy, high incidence of postoperative nausea and vomiting (PONV) remains a major cause of morbidity. The aim of the present study was to investigate the effect of single dose of dexamethasone on PONV in patients undergoing laparoscopic cholecystectomy. METHODS: This clinical trial study included 92 patients undergoing laparoscopic cholecystectomy. We divided the patients into two groups randomly. One group received Dexamethasone (5mg, IV) and the other group received Saline (5cc, IV) 10 minutes before extubation. The patients were observed for any episode and severity of nausea and vomiting or whether the patient required any anti emetic drug in the 24 hours postoperative period. FINDINGS: Two patients in saline group excluded the study. There were no significant differences between groups regarding to age, gender and body mass index. Incidence of nausea in dexamethasone and saline groups were 34.8% (16) and 47.7% (21) respectively. The difference was not significant (RR=0.73, CI 95%: 0.44-1.20, p=0.310). Also incidence of vomiting in dexamethasone and saline groups were 30.4% (14) and 34.1% (15) respectively, and the difference was not significant (RR=0.89, CI 95%: 0.49-1.69, p=0.884). CONCLUSION: Our study has shown that a single dose dexamethasone (5mg, IV), 10 minutes before extubation, has no effect on PONV.http://jbums.org/browse.php?a_code=A-10-1050-3&slc_lang=en&sid=1KEY WORDS: Postoperative nausea and VomitingLaparoscopic cholecystectomyDexamethasone. |
| spellingShingle | hamidreza Hemmati raheb Ghorbani babak Hossein-Zadeh hadith Ebrahim-Zadeh saeed Shakeri The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul KEY WORDS: Postoperative nausea and Vomiting Laparoscopic cholecystectomy Dexamethasone. |
| title | The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy |
| title_full | The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy |
| title_fullStr | The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy |
| title_full_unstemmed | The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy |
| title_short | The Effect of Single Dose of Dexamethasone on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy |
| title_sort | effect of single dose of dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy |
| topic | KEY WORDS: Postoperative nausea and Vomiting Laparoscopic cholecystectomy Dexamethasone. |
| url | http://jbums.org/browse.php?a_code=A-10-1050-3&slc_lang=en&sid=1 |
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