Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance

Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance

Taxanes are a class of chemotherapeutic agents that inhibit cell division by disrupting the mitotic spindle through the stabilization of microtubules. Most breast cancer (BC) tumors show resistance against taxanes partially due to alterations in tubulin genes. In this project we investigated tubulin...

Full description

Bibliographic Details
Main Authors: Babak Nami, Zhixiang Wang
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Cancers
Subjects:
breast cancer
tubulin
tubulin βIII (TUBB3)
taxane resistance
mRNA expression
gene alteration
mutation
H3K4me3
Online Access:http://www.mdpi.com/2072-6694/10/8/274

Similar Items

Similar Items