Vibrio cholerae as a predator: lessons from evolutionary principles
Diarrheal diseases are the second-most common cause of death among children under the age of five worldwide. Cholera alone, caused by the marine bacterium Vibrio cholerae, is responsible for several million cases and over 120,000 deaths annually. When contaminated water is ingested, V. cholerae pass...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00384/full |
| _version_ | 1818580685991968768 |
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| author | Stefan ePukatzki Daniele eProvenzano |
| author_facet | Stefan ePukatzki Daniele eProvenzano |
| author_sort | Stefan ePukatzki |
| collection | DOAJ |
| description | Diarrheal diseases are the second-most common cause of death among children under the age of five worldwide. Cholera alone, caused by the marine bacterium Vibrio cholerae, is responsible for several million cases and over 120,000 deaths annually. When contaminated water is ingested, V. cholerae passes through the gastric acid barrier, penetrates the mucin layer of the small intestine, and adheres to the underlying epithelial lining. V. cholerae multiplies rapidly, secretes cholera toxin, and exits the human host in vast numbers during diarrheal purges. How V. cholerae rapidly reaches such high numbers during each purge is not clearly understood. We propose that V. cholerae employs its bactericidal type VI secretion system to engage in intraspecies and intraguild predation for nutrient acquisition to support rapid growth and multiplication. |
| first_indexed | 2024-12-16T07:21:32Z |
| format | Article |
| id | doaj.art-334551e38adb490fa91ed1c199278978 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-16T07:21:32Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-334551e38adb490fa91ed1c1992789782022-12-21T22:39:37ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2013-12-01410.3389/fmicb.2013.0038470337Vibrio cholerae as a predator: lessons from evolutionary principlesStefan ePukatzki0Daniele eProvenzano1University of AlbertaUniversity of Texas BrownsvilleDiarrheal diseases are the second-most common cause of death among children under the age of five worldwide. Cholera alone, caused by the marine bacterium Vibrio cholerae, is responsible for several million cases and over 120,000 deaths annually. When contaminated water is ingested, V. cholerae passes through the gastric acid barrier, penetrates the mucin layer of the small intestine, and adheres to the underlying epithelial lining. V. cholerae multiplies rapidly, secretes cholera toxin, and exits the human host in vast numbers during diarrheal purges. How V. cholerae rapidly reaches such high numbers during each purge is not clearly understood. We propose that V. cholerae employs its bactericidal type VI secretion system to engage in intraspecies and intraguild predation for nutrient acquisition to support rapid growth and multiplication.http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00384/fullCholeraVibrio choleraenutrient acquisitiontype 6 secretion systemmicrobiome modificationintraguild predation |
| spellingShingle | Stefan ePukatzki Daniele eProvenzano Vibrio cholerae as a predator: lessons from evolutionary principles Frontiers in Microbiology Cholera Vibrio cholerae nutrient acquisition type 6 secretion system microbiome modification intraguild predation |
| title | Vibrio cholerae as a predator: lessons from evolutionary principles |
| title_full | Vibrio cholerae as a predator: lessons from evolutionary principles |
| title_fullStr | Vibrio cholerae as a predator: lessons from evolutionary principles |
| title_full_unstemmed | Vibrio cholerae as a predator: lessons from evolutionary principles |
| title_short | Vibrio cholerae as a predator: lessons from evolutionary principles |
| title_sort | vibrio cholerae as a predator lessons from evolutionary principles |
| topic | Cholera Vibrio cholerae nutrient acquisition type 6 secretion system microbiome modification intraguild predation |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00384/full |
| work_keys_str_mv | AT stefanepukatzki vibriocholeraeasapredatorlessonsfromevolutionaryprinciples AT danieleeprovenzano vibriocholeraeasapredatorlessonsfromevolutionaryprinciples |