Effects of Soy Isoflavones and Green Tea Extract on Simvastatin Pharmacokinetics and Influence of the SLCO1B1 521T > C Polymorphism

Effects of Soy Isoflavones and Green Tea Extract on Simvastatin Pharmacokinetics and Influence of the SLCO1B1 521T > C Polymorphism

ObjectivesGreen tea and soy products are extensively consumed by many people and they may influence the activity of drug metabolizing enzymes and drug transporters to result in drug interactions. This study was performed to evaluate the effect of green tea and soy isoflavone extracts on the pharmaco...

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Bibliographic Details
Main Authors: Weiwei Zeng, Miao Hu, Hon Kit Lee, Elaine Wat, Clara Bik San Lau, Chung Shun Ho, Chun Kwok Wong, Brian Tomlinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Nutrition
Subjects:
SLCO1B1
drug interaction
EGCG
green tea
simvastatin
soy isoflavones
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.868126/full

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