Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study
In this register-based real-life cohort study, changes in symptom-specific hospital contacts among 12–18-year-olds following two doses of the BNT162b2 COVID-19 vaccine compared to unvaccinated peers were investigated. Using national register data, vaccinated and unvaccinated adolescents were sex and...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/6/1049 |
| _version_ | 1827735429862916096 |
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| author | Selina Kikkenborg Berg Helle Wallach-Kildemoes Line Ryberg Rasmussen Ulrikka Nygaard Nina Marie Birk Henning Bundgaard Annette Kjær Ersbøll Lau Caspar Thygesen Susanne Dam Nielsen Anne Vinggaard Christensen |
| author_facet | Selina Kikkenborg Berg Helle Wallach-Kildemoes Line Ryberg Rasmussen Ulrikka Nygaard Nina Marie Birk Henning Bundgaard Annette Kjær Ersbøll Lau Caspar Thygesen Susanne Dam Nielsen Anne Vinggaard Christensen |
| author_sort | Selina Kikkenborg Berg |
| collection | DOAJ |
| description | In this register-based real-life cohort study, changes in symptom-specific hospital contacts among 12–18-year-olds following two doses of the BNT162b2 COVID-19 vaccine compared to unvaccinated peers were investigated. Using national register data, vaccinated and unvaccinated adolescents were sex and age-matched each week during the inclusion period from May to September 2021. Symptom-specific hospital contacts covering ICD-10 R diagnoses were assessed before first the vaccine dose and after the second vaccine dose. Taking previous rates of symptom-specific hospital contacts into account, differences between vaccinated and unvaccinated adolescents were found. For some hospital contacts, higher rates were seen among the vaccinated, and for others, higher rates were seen among the unvaccinated. Unspecific cognition symptoms may be important to monitor in vaccinated girls, and likewise for throat and chest pain in vaccinated boys within the first months post-vaccination. In perspective, symptom-specific hospital contacts after vaccination against COVID-19 must be assessed by taking the risk of infection and symptoms following COVID-19 infection into account. |
| first_indexed | 2024-03-11T01:50:49Z |
| format | Article |
| id | doaj.art-33474a8237f844c4af494398ff080043 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T01:50:49Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-33474a8237f844c4af494398ff0800432023-11-18T12:58:30ZengMDPI AGVaccines2076-393X2023-05-01116104910.3390/vaccines11061049Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort StudySelina Kikkenborg Berg0Helle Wallach-Kildemoes1Line Ryberg Rasmussen2Ulrikka Nygaard3Nina Marie Birk4Henning Bundgaard5Annette Kjær Ersbøll6Lau Caspar Thygesen7Susanne Dam Nielsen8Anne Vinggaard Christensen9Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100 Copenhagen, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100 Copenhagen, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100 Copenhagen, DenmarkFaculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100 Copenhagen, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100 Copenhagen, DenmarkNational Institute of Public Health, University of Southern Denmark, Studiestræde 6, 1455 Copenhagen, DenmarkNational Institute of Public Health, University of Southern Denmark, Studiestræde 6, 1455 Copenhagen, DenmarkFaculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, DenmarkDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100 Copenhagen, DenmarkIn this register-based real-life cohort study, changes in symptom-specific hospital contacts among 12–18-year-olds following two doses of the BNT162b2 COVID-19 vaccine compared to unvaccinated peers were investigated. Using national register data, vaccinated and unvaccinated adolescents were sex and age-matched each week during the inclusion period from May to September 2021. Symptom-specific hospital contacts covering ICD-10 R diagnoses were assessed before first the vaccine dose and after the second vaccine dose. Taking previous rates of symptom-specific hospital contacts into account, differences between vaccinated and unvaccinated adolescents were found. For some hospital contacts, higher rates were seen among the vaccinated, and for others, higher rates were seen among the unvaccinated. Unspecific cognition symptoms may be important to monitor in vaccinated girls, and likewise for throat and chest pain in vaccinated boys within the first months post-vaccination. In perspective, symptom-specific hospital contacts after vaccination against COVID-19 must be assessed by taking the risk of infection and symptoms following COVID-19 infection into account.https://www.mdpi.com/2076-393X/11/6/1049COVID-19children and adolescentsvaccinesymptoms |
| spellingShingle | Selina Kikkenborg Berg Helle Wallach-Kildemoes Line Ryberg Rasmussen Ulrikka Nygaard Nina Marie Birk Henning Bundgaard Annette Kjær Ersbøll Lau Caspar Thygesen Susanne Dam Nielsen Anne Vinggaard Christensen Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study Vaccines COVID-19 children and adolescents vaccine symptoms |
| title | Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study |
| title_full | Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study |
| title_fullStr | Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study |
| title_full_unstemmed | Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study |
| title_short | Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study |
| title_sort | symptom specific hospital contacts in 12 18 year olds vaccinated against covid 19 a danish register based cohort study |
| topic | COVID-19 children and adolescents vaccine symptoms |
| url | https://www.mdpi.com/2076-393X/11/6/1049 |
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