Targeting Viral and Cellular Cysteine Proteases for Treatment of New Variants of SARS-CoV-2

Targeting Viral and Cellular Cysteine Proteases for Treatment of New Variants of SARS-CoV-2

The continuous emergence of SARS-CoV-2 variants caused the persistence of the COVID-19 epidemic and challenged the effectiveness of the existing vaccines. The viral proteases are the most attractive targets for developing antiviral drugs. In this scenario, our study explores the use of HIV-1 proteas...

Full description

Bibliographic Details
Main Authors:	Davide Gentile, Lucia Chiummiento, Alessandro Santarsiere, Maria Funicello, Paolo Lupattelli, Antonio Rescifina, Assunta Venuti, Anna Piperno, Maria Teresa Sciortino, Rosamaria Pennisi
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	Viruses
Subjects:	SARS-CoV-2 cysteine protease pseudovirus technology
Online Access:	https://www.mdpi.com/1999-4915/16/3/338

Similar Items

Identification and Functional Analysis of a Pseudo-Cysteine Protease from the Midgut Transcriptome of <i>Sphenophorus levis</i>
by: Priscila Yumi Tanaka Shibao, et al.
Published: (2021-10-01)

Roles of Cysteine Proteases in Biology and Pathogenesis of Parasites
by: Nawu Yang, et al.
Published: (2023-05-01)

An Integrated In Silico and In Vitro Approach for the Identification of Natural Products Active against SARS-CoV-2
by: Rosamaria Pennisi, et al.
Published: (2023-12-01)

Structure determinants defining the specificity of papain-like cysteine proteases
by: Anastasiia I. Petushkova, et al.
Published: (2022-01-01)

The role of lysosomal cysteine proteases in crustacean immune response
by: FL Garcia-Carreño, et al.
Published: (2014-04-01)

Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro
by: Thị Lam Thái, et al.
Published: (2020-01-01)

Cocaprins, β-Trefoil Fold Inhibitors of Cysteine and Aspartic Proteases from <i>Coprinopsis cinerea</i>
by: Miha Renko, et al.
Published: (2022-04-01)

The Cysteine Protease–Cysteine Protease Inhibitor System Explored in Soybean Nodule Development
by: Marian Dorcas Quain, et al.
Published: (2013-08-01)

Extracellular Cysteine Proteases of Key Intestinal Protozoan Pathogens—Factors Linked to Virulence and Pathogenicity
by: Raúl Argüello-García, et al.
Published: (2023-08-01)

A cysteine protease from the latex of Ficus benjamina has in vitro anthelmintic activity against Haemonchus contortus
by: Ledia Feitosa Wanderley, et al.
Published: (2018-11-01)

Biocatalysts based on complexes of carbon nanomaterials with cysteine proteases
by: Svetlana S. Goncharova, et al.
Published: (2023-09-01)

A cysteine protease inhibitor GC376 displays potent antiviral activity against coxsackievirus infection
by: Yongkang Chen, et al.
Published: (2023-01-01)

Computational Purposing Phytochemicals against Cysteine Protease of Monkeypox Virus: An In-silico Approach
by: Poonam Bansal, et al.
Published: (2022-12-01)

The Effects of pH and Temperature on Cysteine Protease (Cathepsin B) Activity in Miracidia and Eggs of Fasciola hepatica
by: Leila KIANIFARD, et al.
Published: (2020-06-01)

Comparison of clinical and environmental isolates of Acanthamoeba based on morphology, protease and gelatinase activity, and the cysteine proteinase gene
by: Gil M. Penuliar, et al.
Published: (2010-06-01)

Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
by: Christoph Gelhaus, et al.
Published: (2008-12-01)

Inhibitor of Cysteine Protease of <i>Plasmodium malariae</i> Regulates Malapains, Endogenous Cysteine Proteases of the Parasite
by: Hương Giang Lê, et al.
Published: (2022-05-01)

pH-Dependent Specificity of Papain-Like Cysteine Proteases Is Determined by S1 Binding Pocket
by: Anastasiia Petushkova, et al.
Published: (2022-11-01)

Differential sialotranscriptomes of unfed and fed Rhipicephalus haemaphysaloides, with particular regard to differentially expressed genes of cysteine proteases
by: Xinmao Yu, et al.
Published: (2015-11-01)

Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases
by: Simone Brogi, et al.
Published: (2022-04-01)

Poultry infected with Mycoplasma gallisepticum or Mycoplasma synoviae produce antibodies to their cysteine protease CysP
by: Ivanka CIZELJ, et al.
Published: (2013-12-01)

Targeting the nsp2 Cysteine Protease of Chikungunya Virus Using FDA Approved Library and Selected Cysteine Protease Inhibitors
by: Prateek Kumar, et al.
Published: (2019-08-01)

Development of Environmentally Friendly Wool Shrink-Proof Finishing Technology Based on L-Cysteine/Protease Treatment Solution System
by: Bo Li, et al.
Published: (2022-11-01)

Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases
by: Livija Tušar, et al.
Published: (2021-01-01)

Characterization of a novel cysteine protease in Trichinella spiralis and its role in larval intrusion, development and fecundity
by: Yuan Yuan Hu, et al.
Published: (2021-08-01)

Structural Transitions of Papain-like Cysteine Proteases: Implications for Sensor Development
by: Srdjan Marković, et al.
Published: (2023-07-01)

Synthesis of the Novel Covalent Cysteine Proteases Inhibitor with Iodoacetic Functional Group
by: Kinga Hartman, et al.
Published: (2020-02-01)

Cysteine and Aspartic Proteases Underlie the Digestion of Egg Yolk Proteins during the Development of Columba livia domestica Embryo
by: SJ Shbailat, et al.
Published: (2022-09-01)

The Interplay of Glycosaminoglycans and Cysteine Cathepsins in Mucopolysaccharidosis
by: Alexis David, et al.
Published: (2023-03-01)

Novel wild type and mutate HIV-1 protease inhibitors containing heteroaryl carboxamides in P2: Synthesis, biological evaluations and in silico ADME prediction
by: Maria Francesca Armentano, et al.
Published: (2023-12-01)

Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors
by: Marton Siklos, et al.
Published: (2015-11-01)

Papain-like cysteine proteases in Carica papaya: lineage-specific gene duplication and expansion
by: Juan Liu, et al.
Published: (2018-01-01)

Unfolding Studies of the Cysteine Protease Baupain, a Papain-Like Enzyme from Leaves of Bauhinia forficata: Effect of pH, Guanidine Hydrochloride and Temperature
by: Rosemeire A. Silva-Lucca, et al.
Published: (2013-12-01)

Cystatin M/E (Cystatin 6): A Janus-Faced Cysteine Protease Inhibitor with Both Tumor-Suppressing and Tumor-Promoting Functions
by: Gilles Lalmanach, et al.
Published: (2021-04-01)

Nanoencaspsulation of cysteine protease for the management of stored grain pest, Sitotroga cerealella (Olivier)
by: Muazzama Batool, et al.
Published: (2021-06-01)

In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease
by: Xin Hu, et al.
Published: (2023-07-01)

Exploring the Fibrin(ogen)olytic, Anticoagulant, and Antithrombotic Activities of Natural Cysteine Protease (Ficin) with the κ-Carrageenan-Induced Rat Tail Thrombosis Model
by: Hye Ryeon Yang, et al.
Published: (2022-08-01)

A Novel Cysteine Protease Inhibitor of <i>Naegleria fowleri</i> That Is Specifically Expressed during Encystation and at Mature Cysts
by: Hương Giang Lê, et al.
Published: (2021-03-01)

The Mammalian Cysteine Protease Legumain in Health and Disease
by: Rigmor Solberg, et al.
Published: (2022-12-01)

A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4–ROS–NLRP3 pathway
by: Jingyun Xu, et al.
Published: (2022-09-01)