Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss
Background: Recurrent pregnancy loss (RPL) is one of the most frustrating and difficult areas in reproductive medicine, because the aetiology is often unknown and there are few evidence-based diagnostic and treatment strategies. RPL diagnosis is mainly focused on the female partner. The male fac...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5172/9109_CE(Ra)_F(Sh)_PF1(PU_Sh)_PFA(Sh)_PF2(PAG).pdf |
| _version_ | 1831523852287475712 |
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| author | Kavitha P Suttur S. Malini |
| author_facet | Kavitha P Suttur S. Malini |
| author_sort | Kavitha P |
| collection | DOAJ |
| description | Background: Recurrent pregnancy loss (RPL) is one of the most
frustrating and difficult areas in reproductive medicine, because
the aetiology is often unknown and there are few evidence-based
diagnostic and treatment strategies. RPL diagnosis is mainly
focused on the female partner. The male factor contributing in
evaluation of RPL has been less investigated, it is restricted to
karyotype and basic semen analysis, assessment of functionality
of sperm is largely ignored.
Aim and Objective: To investigate the role of sperm factors
in RPL through regular semen analysis preceded with sperm
function tests.
Materials and Methods: We performed a case control study
of 95 males whose partner has experienced two or more
pregnancy loss as case and 37 volunteers who had fathered
child/children without the history of RPL as control group. Basic
semen analysis and sperm function test (Nuclear chromatin
decondensation {NCD}, Hypo osmotic swelling {HOS} and
Acrosome intactness test {AIT} was performed. The results
were analysed by performing Independent-sample t-test using
SPSS (version 14.0).
Results: One individual had anatomical abnormality which was
confirmed through trans-rectal ultrasound scanning and RPL
group showed statistically significant (p<0.05) value for NCD,
HOS and AIT and 36.8% of RPL individuals had reduced score
for sperm count and motility. Less than 4% normal morphology
was recorded in 16.8% individuals of RPL group.
Conclusion: Our study revealed that the positive association of
sperm dysfunction in RPL cases, hence male may be considered
for a routine part of the evaluation along with his partner in the
near future in order to achieve desirable outcome. |
| first_indexed | 2024-12-14T20:14:05Z |
| format | Article |
| id | doaj.art-334a01fe738a4a5e86c60d6c35bd2291 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T20:14:05Z |
| publishDate | 2014-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-334a01fe738a4a5e86c60d6c35bd22912022-12-21T22:48:53ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-11-01811OC07OC1010.7860/JCDR/2014/9109.5172Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy LossKavitha P0Suttur S. Malini1Junior Research Scholar, Department of Studies in Zoology, Manasagangotri, Mysore, Karnataka, India.Assistant Professor, Department of Studies in Zoology, Manasagangotri, Mysore, Karnataka, India.Background: Recurrent pregnancy loss (RPL) is one of the most frustrating and difficult areas in reproductive medicine, because the aetiology is often unknown and there are few evidence-based diagnostic and treatment strategies. RPL diagnosis is mainly focused on the female partner. The male factor contributing in evaluation of RPL has been less investigated, it is restricted to karyotype and basic semen analysis, assessment of functionality of sperm is largely ignored. Aim and Objective: To investigate the role of sperm factors in RPL through regular semen analysis preceded with sperm function tests. Materials and Methods: We performed a case control study of 95 males whose partner has experienced two or more pregnancy loss as case and 37 volunteers who had fathered child/children without the history of RPL as control group. Basic semen analysis and sperm function test (Nuclear chromatin decondensation {NCD}, Hypo osmotic swelling {HOS} and Acrosome intactness test {AIT} was performed. The results were analysed by performing Independent-sample t-test using SPSS (version 14.0). Results: One individual had anatomical abnormality which was confirmed through trans-rectal ultrasound scanning and RPL group showed statistically significant (p<0.05) value for NCD, HOS and AIT and 36.8% of RPL individuals had reduced score for sperm count and motility. Less than 4% normal morphology was recorded in 16.8% individuals of RPL group. Conclusion: Our study revealed that the positive association of sperm dysfunction in RPL cases, hence male may be considered for a routine part of the evaluation along with his partner in the near future in order to achieve desirable outcome.https://jcdr.net/articles/PDF/5172/9109_CE(Ra)_F(Sh)_PF1(PU_Sh)_PFA(Sh)_PF2(PAG).pdfspermatozoasemen parameterssperm function tests |
| spellingShingle | Kavitha P Suttur S. Malini Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss Journal of Clinical and Diagnostic Research spermatozoa semen parameters sperm function tests |
| title | Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss |
| title_full | Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss |
| title_fullStr | Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss |
| title_full_unstemmed | Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss |
| title_short | Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss |
| title_sort | positive association of sperm dysfunction in the pathogenesis of recurrent pregnancy loss |
| topic | spermatozoa semen parameters sperm function tests |
| url | https://jcdr.net/articles/PDF/5172/9109_CE(Ra)_F(Sh)_PF1(PU_Sh)_PFA(Sh)_PF2(PAG).pdf |
| work_keys_str_mv | AT kavithap positiveassociationofspermdysfunctioninthepathogenesisofrecurrentpregnancyloss AT suttursmalini positiveassociationofspermdysfunctioninthepathogenesisofrecurrentpregnancyloss |