Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure
Despite a massive global preventative effort, heart failure remains the major cause of death globally. The number of patients requiring a heart transplant, the eventual last treatment option, far outnumbers the available donor hearts, leaving many to deteriorate or die on the transplant waiting list...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/9/3/93 |
| _version_ | 1797472748541313024 |
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| author | Niina Matthews Berto Pandolfo Daniel Moses Carmine Gentile |
| author_facet | Niina Matthews Berto Pandolfo Daniel Moses Carmine Gentile |
| author_sort | Niina Matthews |
| collection | DOAJ |
| description | Despite a massive global preventative effort, heart failure remains the major cause of death globally. The number of patients requiring a heart transplant, the eventual last treatment option, far outnumbers the available donor hearts, leaving many to deteriorate or die on the transplant waiting list. Treating heart failure by transplanting a 3D bioprinted patient-specific cardiac patch to the infarcted region on the myocardium has been investigated as a potential future treatment. To date, several studies have created cardiac patches using 3D bioprinting; however, testing the concept is still at a pre-clinical stage. A handful of clinical studies have been conducted. However, moving from animal studies to human trials will require an increase in research in this area. This review covers key elements to the design of a patient-specific cardiac patch, divided into general areas of biological design and 3D modelling. It will make recommendations on incorporating anatomical considerations and high-definition motion data into the process of 3D-bioprinting a patient-specific cardiac patch. |
| first_indexed | 2024-03-09T20:06:34Z |
| format | Article |
| id | doaj.art-334ab411802442f0a6b9977ecbc8af1b |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T20:06:34Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-334ab411802442f0a6b9977ecbc8af1b2023-11-24T00:30:08ZengMDPI AGBioengineering2306-53542022-02-01939310.3390/bioengineering9030093Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart FailureNiina Matthews0Berto Pandolfo1Daniel Moses2Carmine Gentile3School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney (UTS), Sydney, NSW 2007, AustraliaSchool of Design, Faculty of Design, Architecture and Building, University of Technology Sydney (UTS), Sydney, NSW 2007, AustraliaResearch Imaging NSW, University of New South Wales (UNSW), Sydney, NSW 2034, AustraliaSchool of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney (UTS), Sydney, NSW 2007, AustraliaDespite a massive global preventative effort, heart failure remains the major cause of death globally. The number of patients requiring a heart transplant, the eventual last treatment option, far outnumbers the available donor hearts, leaving many to deteriorate or die on the transplant waiting list. Treating heart failure by transplanting a 3D bioprinted patient-specific cardiac patch to the infarcted region on the myocardium has been investigated as a potential future treatment. To date, several studies have created cardiac patches using 3D bioprinting; however, testing the concept is still at a pre-clinical stage. A handful of clinical studies have been conducted. However, moving from animal studies to human trials will require an increase in research in this area. This review covers key elements to the design of a patient-specific cardiac patch, divided into general areas of biological design and 3D modelling. It will make recommendations on incorporating anatomical considerations and high-definition motion data into the process of 3D-bioprinting a patient-specific cardiac patch.https://www.mdpi.com/2306-5354/9/3/933D bioprintingpatient-specificcardiac patchheart failure3D modelling |
| spellingShingle | Niina Matthews Berto Pandolfo Daniel Moses Carmine Gentile Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure Bioengineering 3D bioprinting patient-specific cardiac patch heart failure 3D modelling |
| title | Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure |
| title_full | Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure |
| title_fullStr | Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure |
| title_full_unstemmed | Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure |
| title_short | Taking It Personally: 3D Bioprinting a Patient-Specific Cardiac Patch for the Treatment of Heart Failure |
| title_sort | taking it personally 3d bioprinting a patient specific cardiac patch for the treatment of heart failure |
| topic | 3D bioprinting patient-specific cardiac patch heart failure 3D modelling |
| url | https://www.mdpi.com/2306-5354/9/3/93 |
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