Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis
Objective: Recent studies have shown that chronic inflammation contributes to the development of sudden sensorineural hearing loss (SSNHL). Some hematologic parameters have also been linked to the prognosis of SSNHL. However, the prognostic value of such hematological factors is not conclusive. This...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Journal of Otology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293020300660 |
| _version_ | 1818821691082539008 |
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| author | Wei Ni Shao-Peng Song Yi-Dao Jiang |
| author_facet | Wei Ni Shao-Peng Song Yi-Dao Jiang |
| author_sort | Wei Ni |
| collection | DOAJ |
| description | Objective: Recent studies have shown that chronic inflammation contributes to the development of sudden sensorineural hearing loss (SSNHL). Some hematologic parameters have also been linked to the prognosis of SSNHL. However, the prognostic value of such hematological factors is not conclusive. This study explored the association of routine hematological parameters with SSNHL. Methods: A systematic literature search was conducted in PubMed, Cochrane Library, Web of Science and Embase to identify eligible studies. Standardized mean deviation (SMD) and the 95% confidence interval (CI) were retried from relevant studies for analysis. Heterogeneity, subgroup, and publication bias analyses were performed. Results: A total of 18 studies involving 1505 SSNHL patients and 1466 healthy persons were enrolled in the final analysis. The study population included 699 responders and 458 non-responders to treatment. Pooled results revealed that the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) value in the SSNHL patient group were higher than in the healthy group (SMD = 1.05, 95% CI: 0.86,1.24, p < 0.001, SMD = 0.52, 95% CI: 0.26,0.78, p < 0.001, respectively). However, there was no significant difference in the mean platelet volumes (MPV) between the groups (SMD = 0.03, 95% CI: 0.44, 0.49, p = 0.91). Notably, NLR and PLR values were evidently higher in the unrecovered group than in the recovered group (SMD = −0.63, 95% CI: 1.02, −0.23, p = 0.002, SMD = −0.4, 95% CI: 0.76, −0.03, p = 0.03, respectively). However, the MPV value was similar in both groups (SMD = −0.35, 95% CI: 1.14,0.44, p = 0.38). Conclusions: Our results show that NLR and PLR values can predict the onset and prognosis of SSNHL. |
| first_indexed | 2024-12-18T23:12:12Z |
| format | Article |
| id | doaj.art-334b04c42f9145488a3c3128f5625eca |
| institution | Directory Open Access Journal |
| issn | 1672-2930 |
| language | English |
| last_indexed | 2024-12-18T23:12:12Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj.art-334b04c42f9145488a3c3128f5625eca2022-12-21T20:48:18ZengElsevierJournal of Otology1672-29302021-01-011614754Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysisWei Ni0Shao-Peng Song1Yi-Dao Jiang2Department of Otolaryngology-Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jing Zhou, 434020, PR ChinaDepartment of Otolaryngology-Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jing Zhou, 434020, PR ChinaCorresponding author. Department of Otolaryngology-Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, No. 60 Jingzhong Road, Jingzhou District, Jingzhou, Hubei, 434020, PR China.; Department of Otolaryngology-Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jing Zhou, 434020, PR ChinaObjective: Recent studies have shown that chronic inflammation contributes to the development of sudden sensorineural hearing loss (SSNHL). Some hematologic parameters have also been linked to the prognosis of SSNHL. However, the prognostic value of such hematological factors is not conclusive. This study explored the association of routine hematological parameters with SSNHL. Methods: A systematic literature search was conducted in PubMed, Cochrane Library, Web of Science and Embase to identify eligible studies. Standardized mean deviation (SMD) and the 95% confidence interval (CI) were retried from relevant studies for analysis. Heterogeneity, subgroup, and publication bias analyses were performed. Results: A total of 18 studies involving 1505 SSNHL patients and 1466 healthy persons were enrolled in the final analysis. The study population included 699 responders and 458 non-responders to treatment. Pooled results revealed that the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) value in the SSNHL patient group were higher than in the healthy group (SMD = 1.05, 95% CI: 0.86,1.24, p < 0.001, SMD = 0.52, 95% CI: 0.26,0.78, p < 0.001, respectively). However, there was no significant difference in the mean platelet volumes (MPV) between the groups (SMD = 0.03, 95% CI: 0.44, 0.49, p = 0.91). Notably, NLR and PLR values were evidently higher in the unrecovered group than in the recovered group (SMD = −0.63, 95% CI: 1.02, −0.23, p = 0.002, SMD = −0.4, 95% CI: 0.76, −0.03, p = 0.03, respectively). However, the MPV value was similar in both groups (SMD = −0.35, 95% CI: 1.14,0.44, p = 0.38). Conclusions: Our results show that NLR and PLR values can predict the onset and prognosis of SSNHL.http://www.sciencedirect.com/science/article/pii/S1672293020300660Sudden sensorineural hearing lossPrognosisNeutrophil/ lymphocyte ratioPlatelet/lymphocyte ratioMeta-analysis |
| spellingShingle | Wei Ni Shao-Peng Song Yi-Dao Jiang Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis Journal of Otology Sudden sensorineural hearing loss Prognosis Neutrophil/ lymphocyte ratio Platelet/lymphocyte ratio Meta-analysis |
| title | Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis |
| title_full | Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis |
| title_fullStr | Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis |
| title_full_unstemmed | Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis |
| title_short | Association between routine hematological parameters and sudden sensorineural hearing loss: A meta-analysis |
| title_sort | association between routine hematological parameters and sudden sensorineural hearing loss a meta analysis |
| topic | Sudden sensorineural hearing loss Prognosis Neutrophil/ lymphocyte ratio Platelet/lymphocyte ratio Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1672293020300660 |
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