Clinical profile and predictors of Severe Dengue disease : A study from South India
Background: Dengue is endemic and prevalent in tropical and sub-tropical countries including India and can cause significant mortality and morbidity. There are limited studies available on factors associated with severe dengue from India, to investigate the predictors of severe dengue in south India...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2018-09-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/browse.php?a_code=A-10-903-1&slc_lang=en&sid=1 |
| _version_ | 1811235710565351424 |
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| author | Vijay Kumar Agrawal Saroj Kumar Prusty Ch Santosh Reddy Gangireddy Krishna Mohan Reddy Rakesh Kumar Agrawal VCS Srinivasarao Bandaru |
| author_facet | Vijay Kumar Agrawal Saroj Kumar Prusty Ch Santosh Reddy Gangireddy Krishna Mohan Reddy Rakesh Kumar Agrawal VCS Srinivasarao Bandaru |
| author_sort | Vijay Kumar Agrawal |
| collection | DOAJ |
| description | Background: Dengue is endemic and prevalent in tropical and sub-tropical countries including India and can cause significant mortality and morbidity. There are limited studies available on factors associated with severe dengue from India, to investigate the predictors of severe dengue in south Indian patients.
Methods: We recruited 334 patients with dengue admitted in Yashoda Hospital, Hyderabad. Study period was between March 2015 and February 2017. Based on clinical symptoms, we divided patients into severe dengue and non-severe dengue. Univariate and multivariate analysis was performed for prognostic factors of severe dengue.
Results: Out of 334 patients, there were 186(55.6%) males with mean age 30.3±14.3 39 years (age range: 10-73 years), severe dengue was seen in 117(35%) and non-severe dengue in 217(65%). Clinical symptoms of diabetes, low platelet count (<50,000mm3), melena, skin rash, delayed admission (>5days after onset) elevated hematocrit, lymphadenopathy, hepatomegaly, splenomegaly, convulsions and mortality were significantly associated with severe dengue. After multivariate analysis, diabetes (OR: 2.12; 95% CI:1.34-4.65) (<0.0001), elevated hematocrit (OR: 3.14; 95% CI:2.17-6.14) (<0.0001), skin rashes (OR: 1.99; 95% CI: 1.11-3.55) (<0.0001), melena (OR: 2.59; 95% CI:1.40-4.93) (<0.0001), low platelet count (OR: 6.71; 95% CI:4.12-13.6) (<0.0001), lymphadenopathy (OR: 3.12 95% CI: 1.91-7.85) (<0.0001) and delayed admission (OR: 2.40; 95% CI:1.31-3.41) (<0.0001) were significantly associated with severe dengue disease.
Conclusions: In our study, it was established that low platelet count, elevated hematocrit, diabetes, skin rash, melena, lymphadenopathy and delayed in admission (>5days) were independently associated with severe dengue. |
| first_indexed | 2024-04-12T11:56:45Z |
| format | Article |
| id | doaj.art-334d093ba4004ec49d3d0871c0bcf2d6 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-04-12T11:56:45Z |
| publishDate | 2018-09-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-334d093ba4004ec49d3d0871c0bcf2d62022-12-22T03:33:59ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722018-09-0194334340Clinical profile and predictors of Severe Dengue disease : A study from South IndiaVijay Kumar Agrawal0Saroj Kumar Prusty1Ch Santosh Reddy2Gangireddy Krishna Mohan Reddy3Rakesh Kumar Agrawal4VCS Srinivasarao Bandaru5 Department of General Medicine, Yashoda Hospital, Hyderabad, India Department of Critical Care, Yashoda Hospital, Hyderabad, India Department of General Medicine, Yashoda Hospital, Hyderabad, India Department of General Medicine, Yashoda Hospital, Hyderabad, India Department of Critical Care, Yashoda Hospital, Hyderabad, India Department of Research, Yashoda Hospital, Hyderabad, India Background: Dengue is endemic and prevalent in tropical and sub-tropical countries including India and can cause significant mortality and morbidity. There are limited studies available on factors associated with severe dengue from India, to investigate the predictors of severe dengue in south Indian patients. Methods: We recruited 334 patients with dengue admitted in Yashoda Hospital, Hyderabad. Study period was between March 2015 and February 2017. Based on clinical symptoms, we divided patients into severe dengue and non-severe dengue. Univariate and multivariate analysis was performed for prognostic factors of severe dengue. Results: Out of 334 patients, there were 186(55.6%) males with mean age 30.3±14.3 39 years (age range: 10-73 years), severe dengue was seen in 117(35%) and non-severe dengue in 217(65%). Clinical symptoms of diabetes, low platelet count (<50,000mm3), melena, skin rash, delayed admission (>5days after onset) elevated hematocrit, lymphadenopathy, hepatomegaly, splenomegaly, convulsions and mortality were significantly associated with severe dengue. After multivariate analysis, diabetes (OR: 2.12; 95% CI:1.34-4.65) (<0.0001), elevated hematocrit (OR: 3.14; 95% CI:2.17-6.14) (<0.0001), skin rashes (OR: 1.99; 95% CI: 1.11-3.55) (<0.0001), melena (OR: 2.59; 95% CI:1.40-4.93) (<0.0001), low platelet count (OR: 6.71; 95% CI:4.12-13.6) (<0.0001), lymphadenopathy (OR: 3.12 95% CI: 1.91-7.85) (<0.0001) and delayed admission (OR: 2.40; 95% CI:1.31-3.41) (<0.0001) were significantly associated with severe dengue disease. Conclusions: In our study, it was established that low platelet count, elevated hematocrit, diabetes, skin rash, melena, lymphadenopathy and delayed in admission (>5days) were independently associated with severe dengue.http://caspjim.com/browse.php?a_code=A-10-903-1&slc_lang=en&sid=1clinical manifestation and laboratory testand delayed in admission severe dengue disease. |
| spellingShingle | Vijay Kumar Agrawal Saroj Kumar Prusty Ch Santosh Reddy Gangireddy Krishna Mohan Reddy Rakesh Kumar Agrawal VCS Srinivasarao Bandaru Clinical profile and predictors of Severe Dengue disease : A study from South India Caspian Journal of Internal Medicine clinical manifestation and laboratory test and delayed in admission severe dengue disease. |
| title | Clinical profile and predictors of Severe Dengue disease : A study from South India |
| title_full | Clinical profile and predictors of Severe Dengue disease : A study from South India |
| title_fullStr | Clinical profile and predictors of Severe Dengue disease : A study from South India |
| title_full_unstemmed | Clinical profile and predictors of Severe Dengue disease : A study from South India |
| title_short | Clinical profile and predictors of Severe Dengue disease : A study from South India |
| title_sort | clinical profile and predictors of severe dengue disease a study from south india |
| topic | clinical manifestation and laboratory test and delayed in admission severe dengue disease. |
| url | http://caspjim.com/browse.php?a_code=A-10-903-1&slc_lang=en&sid=1 |
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