Functional role of miR-34a in diabetes and frailty
Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2022.949924/full |
| _version_ | 1811217499939667968 |
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| author | Pasquale Mone Pasquale Mone Antonio de Donato Fahimeh Varzideh Urna Kansakar Stanislovas S. Jankauskas Antonella Pansini Gaetano Santulli Gaetano Santulli |
| author_facet | Pasquale Mone Pasquale Mone Antonio de Donato Fahimeh Varzideh Urna Kansakar Stanislovas S. Jankauskas Antonella Pansini Gaetano Santulli Gaetano Santulli |
| author_sort | Pasquale Mone |
| collection | DOAJ |
| description | Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments. |
| first_indexed | 2024-04-12T06:55:50Z |
| format | Article |
| id | doaj.art-334e7625a0c74543bb1e1e53899fac74 |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-04-12T06:55:50Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-334e7625a0c74543bb1e1e53899fac742022-12-22T03:43:09ZengFrontiers Media S.A.Frontiers in Aging2673-62172022-07-01310.3389/fragi.2022.949924949924Functional role of miR-34a in diabetes and frailtyPasquale Mone0Pasquale Mone1Antonio de Donato2Fahimeh Varzideh3Urna Kansakar4Stanislovas S. Jankauskas5Antonella Pansini6Gaetano Santulli7Gaetano Santulli8Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, United StatesASL Avellino, Avellino, ItalyBIOGEM, Ariano Irpino, ItalyDivision of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, United StatesDivision of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, United StatesDivision of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, United StatesASL Avellino, Avellino, ItalyDivision of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, United StatesDepartment of Molecular Pharmacology, Einstein Institute for Aging Research, Einstein-Sinai Diabetes Research Center, Albert Einstein College of Medicine, New York, NY, United StatesEmerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.https://www.frontiersin.org/articles/10.3389/fragi.2022.949924/fullmiRNAmiR-34frailtydiabetesaging |
| spellingShingle | Pasquale Mone Pasquale Mone Antonio de Donato Fahimeh Varzideh Urna Kansakar Stanislovas S. Jankauskas Antonella Pansini Gaetano Santulli Gaetano Santulli Functional role of miR-34a in diabetes and frailty Frontiers in Aging miRNA miR-34 frailty diabetes aging |
| title | Functional role of miR-34a in diabetes and frailty |
| title_full | Functional role of miR-34a in diabetes and frailty |
| title_fullStr | Functional role of miR-34a in diabetes and frailty |
| title_full_unstemmed | Functional role of miR-34a in diabetes and frailty |
| title_short | Functional role of miR-34a in diabetes and frailty |
| title_sort | functional role of mir 34a in diabetes and frailty |
| topic | miRNA miR-34 frailty diabetes aging |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2022.949924/full |
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