Gut flora connects obesity with pathological angiogenesis in the eye
Neovascular age‐related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well‐known predisposing factor for nvAMD but how this metabolic disorder modulate...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2016-12-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201607165 |
| _version_ | 1797280633144213504 |
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| author | Rebecca Scholz Thomas Langmann |
| author_facet | Rebecca Scholz Thomas Langmann |
| author_sort | Rebecca Scholz |
| collection | DOAJ |
| description | Neovascular age‐related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well‐known predisposing factor for nvAMD but how this metabolic disorder modulates angiogenesis in the posterior eye segment was largely unknown. In this issue of EMBO Molecular Medicine, Andriessen et al () show that high‐fat diet‐induced obesity causes dysbiosis in the gut that drives retinal inflammation and pathological angiogenesis in a mouse model of laser‐induced choroidal neovascularization (CNV). |
| first_indexed | 2024-03-07T16:44:05Z |
| format | Article |
| id | doaj.art-3350ac80783a4f2682d9ee69cebaec77 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-03-07T16:44:05Z |
| publishDate | 2016-12-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-3350ac80783a4f2682d9ee69cebaec772024-03-03T07:05:20ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842016-12-018121361136310.15252/emmm.201607165Gut flora connects obesity with pathological angiogenesis in the eyeRebecca Scholz0Thomas Langmann1Laboratory for Experimental Immunology of the Eye Department of Ophthalmology University of Cologne Cologne GermanyLaboratory for Experimental Immunology of the Eye Department of Ophthalmology University of Cologne Cologne GermanyNeovascular age‐related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well‐known predisposing factor for nvAMD but how this metabolic disorder modulates angiogenesis in the posterior eye segment was largely unknown. In this issue of EMBO Molecular Medicine, Andriessen et al () show that high‐fat diet‐induced obesity causes dysbiosis in the gut that drives retinal inflammation and pathological angiogenesis in a mouse model of laser‐induced choroidal neovascularization (CNV).https://doi.org/10.15252/emmm.201607165 |
| spellingShingle | Rebecca Scholz Thomas Langmann Gut flora connects obesity with pathological angiogenesis in the eye EMBO Molecular Medicine |
| title | Gut flora connects obesity with pathological angiogenesis in the eye |
| title_full | Gut flora connects obesity with pathological angiogenesis in the eye |
| title_fullStr | Gut flora connects obesity with pathological angiogenesis in the eye |
| title_full_unstemmed | Gut flora connects obesity with pathological angiogenesis in the eye |
| title_short | Gut flora connects obesity with pathological angiogenesis in the eye |
| title_sort | gut flora connects obesity with pathological angiogenesis in the eye |
| url | https://doi.org/10.15252/emmm.201607165 |
| work_keys_str_mv | AT rebeccascholz gutfloraconnectsobesitywithpathologicalangiogenesisintheeye AT thomaslangmann gutfloraconnectsobesitywithpathologicalangiogenesisintheeye |