Regulation of Cox-2 by Cyclic AMP Response Element Binding Protein in Prostate Cancer: Potential Role for Nexrutine

Regulation of Cox-2 by Cyclic AMP Response Element Binding Protein in Prostate Cancer: Potential Role for Nexrutine

We recently showed that NexrutineR, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Our data also indicate that the antiproliferative effects of NexrutineR are mediat...

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Bibliographic Details
Main Authors: Rita Ghosh, Gretchen E. Garcia, Katherine Crosby, Hiroyasu Inoue, Ian M. Thompson, Dean A. Troyer, Addanki P. Kumar
Format: Article
Language:English
Published: Elsevier 2007-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Cox-2 promoter activity
prostate cancer
CREB
inflammation
PGE2
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800170

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