Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected Gastritis
Gastritis is an inflammatory process in the gastric mucosa and submucosa caused by <i>Helicobacter pylori</i> (<i>H. pylori</i>). The infection modulates immune components, such as interleukin (IL) 17, high sensitivity C-reactive protein (hsCRP) and pepsinogen. This study aim...
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MDPI AG
2024-01-01
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| Series: | Gastroenterology Insights |
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| Online Access: | https://www.mdpi.com/2036-7422/15/1/3 |
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| author | Jeanne Winarta Bradley Jimmy Waleleng Nelly Tandean Wenas Fujiyanto Oscar Miguna Marco Rahardja |
| author_facet | Jeanne Winarta Bradley Jimmy Waleleng Nelly Tandean Wenas Fujiyanto Oscar Miguna Marco Rahardja |
| author_sort | Jeanne Winarta |
| collection | DOAJ |
| description | Gastritis is an inflammatory process in the gastric mucosa and submucosa caused by <i>Helicobacter pylori</i> (<i>H. pylori</i>). The infection modulates immune components, such as interleukin (IL) 17, high sensitivity C-reactive protein (hsCRP) and pepsinogen. This study aimed to determine the relationship between IL-17, hsCRP and pepsinogen in <i>H. pylori</i> infected gastritis. This observational cross-sectional study was conducted at Prof. Dr. R. D. Kandou General Hospital Manado from May-July 2022. Measurement of blood sample levels of IL-17, hsCRP, pepsinogen I, pepsinogen II and pepsinogen I/II ratio. Spearman’s statistical test was used to determine correlations between these variables. This study involved 48 patients aged 21–64, with a majority of females (67%). IL-7 had a positive correlation with pepsinogen I (r = 0.292; <i>p</i> = 0.044) and pepsinogen II (r = 0.288; <i>p</i> = 0.047) in <i>H. pylori</i> infected gastritis. Meanwhile, IL-17 with pepsinogen I/II ratio, hsCRP with pepsinogen I, pepsinogen II, pepsinogen I/II ratio and IL-17 with hsCRP did not show a significant correlation (<i>p</i> > 0.05). There was a correlation between IL 17 to pepsinogen I and pepsinogen II in gastritis infected with <i>H. pylori</i>, suggesting the importance of these early markers of inflammation in determining the severity of gastric mucosal inflammation in pylori-infected patients. |
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| language | English |
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| spelling | doaj.art-3352d75a2c0540fb9e8d9f212b7de9c82024-03-27T13:42:26ZengMDPI AGGastroenterology Insights2036-74142036-74222024-01-01151324110.3390/gastroent15010003Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected GastritisJeanne Winarta0Bradley Jimmy Waleleng1Nelly Tandean Wenas2Fujiyanto3Oscar Miguna4Marco Rahardja5Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University/Prof. Dr. R. D. Kandou Hospital, Manado 95115, IndonesiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University/Prof. Dr. R. D. Kandou Hospital, Manado 95115, IndonesiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Sam Ratulangi University/Prof. Dr. R. D. Kandou Hospital, Manado 95115, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sam Ratulangi University/Prof. Dr. R. D. Kandou Hospital, Manado 95115, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sam Ratulangi University/Prof. Dr. R. D. Kandou Hospital, Manado 95115, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Sam Ratulangi University/Prof. Dr. R. D. Kandou Hospital, Manado 95115, IndonesiaGastritis is an inflammatory process in the gastric mucosa and submucosa caused by <i>Helicobacter pylori</i> (<i>H. pylori</i>). The infection modulates immune components, such as interleukin (IL) 17, high sensitivity C-reactive protein (hsCRP) and pepsinogen. This study aimed to determine the relationship between IL-17, hsCRP and pepsinogen in <i>H. pylori</i> infected gastritis. This observational cross-sectional study was conducted at Prof. Dr. R. D. Kandou General Hospital Manado from May-July 2022. Measurement of blood sample levels of IL-17, hsCRP, pepsinogen I, pepsinogen II and pepsinogen I/II ratio. Spearman’s statistical test was used to determine correlations between these variables. This study involved 48 patients aged 21–64, with a majority of females (67%). IL-7 had a positive correlation with pepsinogen I (r = 0.292; <i>p</i> = 0.044) and pepsinogen II (r = 0.288; <i>p</i> = 0.047) in <i>H. pylori</i> infected gastritis. Meanwhile, IL-17 with pepsinogen I/II ratio, hsCRP with pepsinogen I, pepsinogen II, pepsinogen I/II ratio and IL-17 with hsCRP did not show a significant correlation (<i>p</i> > 0.05). There was a correlation between IL 17 to pepsinogen I and pepsinogen II in gastritis infected with <i>H. pylori</i>, suggesting the importance of these early markers of inflammation in determining the severity of gastric mucosal inflammation in pylori-infected patients.https://www.mdpi.com/2036-7422/15/1/3interleukin-17hsCRPpepsinogen Ipepsinogen IIpepsinogen ratio I/II<i>Helicobacter pylori</i> |
| spellingShingle | Jeanne Winarta Bradley Jimmy Waleleng Nelly Tandean Wenas Fujiyanto Oscar Miguna Marco Rahardja Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected Gastritis Gastroenterology Insights interleukin-17 hsCRP pepsinogen I pepsinogen II pepsinogen ratio I/II <i>Helicobacter pylori</i> |
| title | Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected Gastritis |
| title_full | Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected Gastritis |
| title_fullStr | Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected Gastritis |
| title_full_unstemmed | Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected Gastritis |
| title_short | Correlation between Interleukin-17, High Sensitivity C-Reactive Protein and Pepsinogen in <i>Helicobacter pylori</i> Infected Gastritis |
| title_sort | correlation between interleukin 17 high sensitivity c reactive protein and pepsinogen in i helicobacter pylori i infected gastritis |
| topic | interleukin-17 hsCRP pepsinogen I pepsinogen II pepsinogen ratio I/II <i>Helicobacter pylori</i> |
| url | https://www.mdpi.com/2036-7422/15/1/3 |
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