Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats
This study aims to investigate the effect of aspirin in methotrexate toxicity (increase or decrease) relating to oxidative stress and histopathological changes of the liver and kidney in male rats. Twenty rats were divided into equal 4 groups, the first is considered control group, the second was tr...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2021-01-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_166835_896a6301473085f5b12eb0aa662f6e53.pdf |
| _version_ | 1818618218556686336 |
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| author | yamama Alabdaly Mohammed saeed Hadeel Al-hashemi |
| author_facet | yamama Alabdaly Mohammed saeed Hadeel Al-hashemi |
| author_sort | yamama Alabdaly |
| collection | DOAJ |
| description | This study aims to investigate the effect of aspirin in methotrexate toxicity (increase or decrease) relating to oxidative stress and histopathological changes of the liver and kidney in male rats. Twenty rats were divided into equal 4 groups, the first is considered control group, the second was treated with methotrexate in a dose of 10 mg/kg, the third was treated with methotrexate and aspirin in doses of 10 and 30 mg/kg respectively, the fourth was treated with aspirin alone with a dose of 30 mg/kg. All doses were given by daily oral dosage for 4 constitutive days. The result revealed a significant decrease in the concentration of both glutathione and albumin and a significant increase in the concentration of both malondialdehyde and ALT enzyme in the two groups treated with methotrexate alone or in combination with aspirin as compared to the control group. The histopathology revealed that the severity of lesions was in the group of methotrexate with aspirin, group of methotrexate only and a group of aspirin respectively, which are representing by coagulative necrosis and hypertrophy of hepatocytes in the liver while the lesions of kidney were atrophy of some glomeruli and renal cystic formation. The study concludes that aspirin increases the toxic effect of methotrexate at the level of oxidative stress concomitant with the occurrence of hepatic and renal toxicity. |
| first_indexed | 2024-12-16T17:18:06Z |
| format | Article |
| id | doaj.art-335334af69d344c0b54e65d5da85b1f2 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-16T17:18:06Z |
| publishDate | 2021-01-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-335334af69d344c0b54e65d5da85b1f22022-12-21T22:23:14ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552021-01-0135115115610.33899/ijvs.2020.126490.1335166835Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in ratsyamama Alabdaly0Mohammed saeed1Hadeel Al-hashemi2vet med, University of Mosul. mosul, IraqUniversity of Mosul - College of Veterinary medicineDepartment of Physiology,Biochemistry and Pharmacology, College of Veterinary Medicine, University of MosulThis study aims to investigate the effect of aspirin in methotrexate toxicity (increase or decrease) relating to oxidative stress and histopathological changes of the liver and kidney in male rats. Twenty rats were divided into equal 4 groups, the first is considered control group, the second was treated with methotrexate in a dose of 10 mg/kg, the third was treated with methotrexate and aspirin in doses of 10 and 30 mg/kg respectively, the fourth was treated with aspirin alone with a dose of 30 mg/kg. All doses were given by daily oral dosage for 4 constitutive days. The result revealed a significant decrease in the concentration of both glutathione and albumin and a significant increase in the concentration of both malondialdehyde and ALT enzyme in the two groups treated with methotrexate alone or in combination with aspirin as compared to the control group. The histopathology revealed that the severity of lesions was in the group of methotrexate with aspirin, group of methotrexate only and a group of aspirin respectively, which are representing by coagulative necrosis and hypertrophy of hepatocytes in the liver while the lesions of kidney were atrophy of some glomeruli and renal cystic formation. The study concludes that aspirin increases the toxic effect of methotrexate at the level of oxidative stress concomitant with the occurrence of hepatic and renal toxicity.https://vetmedmosul.com/article_166835_896a6301473085f5b12eb0aa662f6e53.pdfmethotrexateaspirinoxidative stresslesionsrats |
| spellingShingle | yamama Alabdaly Mohammed saeed Hadeel Al-hashemi Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats Iraqi Journal of Veterinary Sciences methotrexate aspirin oxidative stress lesions rats |
| title | Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats |
| title_full | Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats |
| title_fullStr | Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats |
| title_full_unstemmed | Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats |
| title_short | Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats |
| title_sort | effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats |
| topic | methotrexate aspirin oxidative stress lesions rats |
| url | https://vetmedmosul.com/article_166835_896a6301473085f5b12eb0aa662f6e53.pdf |
| work_keys_str_mv | AT yamamaalabdaly effectofmethotrexateandaspirininteractionanditsrelationshiptooxidativestressinrats AT mohammedsaeed effectofmethotrexateandaspirininteractionanditsrelationshiptooxidativestressinrats AT hadeelalhashemi effectofmethotrexateandaspirininteractionanditsrelationshiptooxidativestressinrats |