PGRS domain structures: Doomed to sail the mycomembrane.
The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the myco...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-09-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1010760 |
| _version_ | 1798000636193669120 |
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| author | Rita Berisio Giovanni Delogu |
| author_facet | Rita Berisio Giovanni Delogu |
| author_sort | Rita Berisio |
| collection | DOAJ |
| description | The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus. |
| first_indexed | 2024-04-11T11:23:29Z |
| format | Article |
| id | doaj.art-3353b6ed95414362bf1395691da38517 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-04-11T11:23:29Z |
| publishDate | 2022-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-3353b6ed95414362bf1395691da385172022-12-22T04:26:21ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742022-09-01189e101076010.1371/journal.ppat.1010760PGRS domain structures: Doomed to sail the mycomembrane.Rita BerisioGiovanni DeloguThe impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.https://doi.org/10.1371/journal.ppat.1010760 |
| spellingShingle | Rita Berisio Giovanni Delogu PGRS domain structures: Doomed to sail the mycomembrane. PLoS Pathogens |
| title | PGRS domain structures: Doomed to sail the mycomembrane. |
| title_full | PGRS domain structures: Doomed to sail the mycomembrane. |
| title_fullStr | PGRS domain structures: Doomed to sail the mycomembrane. |
| title_full_unstemmed | PGRS domain structures: Doomed to sail the mycomembrane. |
| title_short | PGRS domain structures: Doomed to sail the mycomembrane. |
| title_sort | pgrs domain structures doomed to sail the mycomembrane |
| url | https://doi.org/10.1371/journal.ppat.1010760 |
| work_keys_str_mv | AT ritaberisio pgrsdomainstructuresdoomedtosailthemycomembrane AT giovannidelogu pgrsdomainstructuresdoomedtosailthemycomembrane |