Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania
The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to Dec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2015-06-01
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| Series: | Balkan Journal of Medical Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bjmg-2015-0002 |
| _version_ | 1797705308979593216 |
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| author | Mierla Dana Malageanu M. Tulin R. Albu D. |
| author_facet | Mierla Dana Malageanu M. Tulin R. Albu D. |
| author_sort | Mierla Dana |
| collection | DOAJ |
| description | The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to December 2011. Two thousand, one hundred and ninety-five patients with reproductive problems were investigated, and the frequency of chromosomal abnormalities was calculated. The control group consisting of 87 fertile persons who had two or more children, was investigated in this retrospective study. All the patients of this study were investigated by cytogenetic techniques and the results of the two groups were compared by a two-tailed Fisher’s exact test. In this study, 94.99% patients had a normal karyotype and 5.01% had chromosomal abnormalities (numerical and structural chromosomal abnormalities). In the study group, numerical chromosomal abnormalities were detected in 1.14% of infertile men and 0.62% of infertile women, and structural chromosomal abnormalities were detected in 1.38% of infertile men and 1.87% of infertile women, respectively. The correlation between the incidence of chromosomal anomalies in the two sexes in couple with reproductive problems was not statistically significant. Recently, a possible association between infertility and chromosomal abnormalities with a significant statistical association has been reported. Our study shows that there is no association between chromosomal abnormalities and infertility, but this study needs to be confirmed with further investigations and a larger control group to establish the role of chromosomal abnormalities in the etiology of infertility. |
| first_indexed | 2024-03-12T05:34:13Z |
| format | Article |
| id | doaj.art-3356205ce611471cbcb767c15732e172 |
| institution | Directory Open Access Journal |
| issn | 1311-0160 |
| language | English |
| last_indexed | 2024-03-12T05:34:13Z |
| publishDate | 2015-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-3356205ce611471cbcb767c15732e1722023-09-03T06:32:20ZengSciendoBalkan Journal of Medical Genetics1311-01602015-06-01181233010.1515/bjmg-2015-0002bjmg-2015-0002Prevalence of Chromosomal Abnormalities in Infertile Couples in RomaniaMierla Dana0Malageanu M.1Tulin R.2Albu D.3Department of Genetics, Life Memorial Hospital, Grivita Street, Bucharest, Romania. Tel: +40-72-147-9083Department of Genetics, Life Memorial Hospital, Bucharest, RomaniaDepartment of Genetics, Life Memorial Hospital, Bucharest, RomaniaDepartment of Genetics, Life Memorial Hospital, Bucharest, RomaniaThe purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to December 2011. Two thousand, one hundred and ninety-five patients with reproductive problems were investigated, and the frequency of chromosomal abnormalities was calculated. The control group consisting of 87 fertile persons who had two or more children, was investigated in this retrospective study. All the patients of this study were investigated by cytogenetic techniques and the results of the two groups were compared by a two-tailed Fisher’s exact test. In this study, 94.99% patients had a normal karyotype and 5.01% had chromosomal abnormalities (numerical and structural chromosomal abnormalities). In the study group, numerical chromosomal abnormalities were detected in 1.14% of infertile men and 0.62% of infertile women, and structural chromosomal abnormalities were detected in 1.38% of infertile men and 1.87% of infertile women, respectively. The correlation between the incidence of chromosomal anomalies in the two sexes in couple with reproductive problems was not statistically significant. Recently, a possible association between infertility and chromosomal abnormalities with a significant statistical association has been reported. Our study shows that there is no association between chromosomal abnormalities and infertility, but this study needs to be confirmed with further investigations and a larger control group to establish the role of chromosomal abnormalities in the etiology of infertility.https://doi.org/10.1515/bjmg-2015-0002chromosomal abnormalitieschromosome polymorphismsinfertility |
| spellingShingle | Mierla Dana Malageanu M. Tulin R. Albu D. Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania Balkan Journal of Medical Genetics chromosomal abnormalities chromosome polymorphisms infertility |
| title | Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania |
| title_full | Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania |
| title_fullStr | Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania |
| title_full_unstemmed | Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania |
| title_short | Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania |
| title_sort | prevalence of chromosomal abnormalities in infertile couples in romania |
| topic | chromosomal abnormalities chromosome polymorphisms infertility |
| url | https://doi.org/10.1515/bjmg-2015-0002 |
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