The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer
Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012002/full |
| _version_ | 1828344159028641792 |
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| author | Jack Gudgeon José Luis Marín-Rubio Matthias Trost |
| author_facet | Jack Gudgeon José Luis Marín-Rubio Matthias Trost |
| author_sort | Jack Gudgeon |
| collection | DOAJ |
| description | Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liver disease, and more recently, cancer. As highlighted throughout this review, the role of MSR1 is often dichotomous, being either host protective or detrimental to the pathogenesis of disease. We will discuss the role of MSR1 in health and disease with a focus on the molecular mechanisms influencing MSR1 expression, how altered expression affects disease process and macrophage function, the limited cell signalling pathways discovered thus far, the emerging role of MSR1 in tumour associated macrophages as well as the therapeutic potential of targeting MSR1. |
| first_indexed | 2024-04-13T23:53:28Z |
| format | Article |
| id | doaj.art-33580f7b62a54f1ebb7e27d63222ef3b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T23:53:28Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-33580f7b62a54f1ebb7e27d63222ef3b2022-12-22T02:24:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10120021012002The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancerJack GudgeonJosé Luis Marín-RubioMatthias TrostMacrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liver disease, and more recently, cancer. As highlighted throughout this review, the role of MSR1 is often dichotomous, being either host protective or detrimental to the pathogenesis of disease. We will discuss the role of MSR1 in health and disease with a focus on the molecular mechanisms influencing MSR1 expression, how altered expression affects disease process and macrophage function, the limited cell signalling pathways discovered thus far, the emerging role of MSR1 in tumour associated macrophages as well as the therapeutic potential of targeting MSR1.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012002/fullMSR1CD204macrophagesimmunologycancerinflammation |
| spellingShingle | Jack Gudgeon José Luis Marín-Rubio Matthias Trost The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer Frontiers in Immunology MSR1 CD204 macrophages immunology cancer inflammation |
| title | The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer |
| title_full | The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer |
| title_fullStr | The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer |
| title_full_unstemmed | The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer |
| title_short | The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer |
| title_sort | role of macrophage scavenger receptor 1 msr1 in inflammatory disorders and cancer |
| topic | MSR1 CD204 macrophages immunology cancer inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012002/full |
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