The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity
Peripheral nervous system (PNS) injuries are an ongoing health care concern. While autografts and allografts are regarded as the current clinical standard for traumatic injury, there are inherent limitations that suggest alternative remedies should be considered for therapeutic purposes. In recent y...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933522000802 |
| _version_ | 1811178854495027200 |
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| author | Corinne S. Smith Jacob A. Orkwis Andrew E. Bryan Zhenyuan Xu Greg M. Harris |
| author_facet | Corinne S. Smith Jacob A. Orkwis Andrew E. Bryan Zhenyuan Xu Greg M. Harris |
| author_sort | Corinne S. Smith |
| collection | DOAJ |
| description | Peripheral nervous system (PNS) injuries are an ongoing health care concern. While autografts and allografts are regarded as the current clinical standard for traumatic injury, there are inherent limitations that suggest alternative remedies should be considered for therapeutic purposes. In recent years, nerve guidance conduits (NGCs) have become increasingly popular as surgical repair devices, with a multitude of various natural and synthetic biomaterials offering potential to enhance the design of conduits or supplant existing technologies entirely. From a cellular perspective, it has become increasingly evident that Schwann cells (SCs), the primary glia of the PNS, are a predominant factor mediating nerve regeneration. Thus, the development of severe nerve trauma therapies requires a deep understanding of how SCs interact with their environment, and how SC microenvironmental cues may be engineered to enhance regeneration. Here we review the most recent advancements in biomaterials development and cell stimulation strategies, with a specific focus on how the microenvironment influences the behavior of SCs and can potentially lead to functional repair. We focus on microenvironmental cues that modulate SC morphology, proliferation, migration, and differentiation to alternative phenotypes. Promotion of regenerative phenotypic responses in SCs and other non-neuronal cells that can augment the regenerative capacity of multiple biomaterials is considered along with innovations and technologies for traumatic injury. |
| first_indexed | 2024-04-11T06:24:51Z |
| format | Article |
| id | doaj.art-335a4d2d994a486c81b1aa10b3920d53 |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-04-11T06:24:51Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-335a4d2d994a486c81b1aa10b3920d532022-12-22T04:40:24ZengElsevierEuropean Journal of Cell Biology0171-93352022-09-011014151277The impact of physical, biochemical, and electrical signaling on Schwann cell plasticityCorinne S. Smith0Jacob A. Orkwis1Andrew E. Bryan2Zhenyuan Xu3Greg M. Harris4Department of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221, USADepartment of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221, USADepartment of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221, USADepartment of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221, USADepartment of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221, USA; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221, USA; Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Correspondence to: Department of Chemical & Environmental Engineering, University of Cincinnati, 2901 Woodside Drive, Cincinnati, OH 45221, USA.Peripheral nervous system (PNS) injuries are an ongoing health care concern. While autografts and allografts are regarded as the current clinical standard for traumatic injury, there are inherent limitations that suggest alternative remedies should be considered for therapeutic purposes. In recent years, nerve guidance conduits (NGCs) have become increasingly popular as surgical repair devices, with a multitude of various natural and synthetic biomaterials offering potential to enhance the design of conduits or supplant existing technologies entirely. From a cellular perspective, it has become increasingly evident that Schwann cells (SCs), the primary glia of the PNS, are a predominant factor mediating nerve regeneration. Thus, the development of severe nerve trauma therapies requires a deep understanding of how SCs interact with their environment, and how SC microenvironmental cues may be engineered to enhance regeneration. Here we review the most recent advancements in biomaterials development and cell stimulation strategies, with a specific focus on how the microenvironment influences the behavior of SCs and can potentially lead to functional repair. We focus on microenvironmental cues that modulate SC morphology, proliferation, migration, and differentiation to alternative phenotypes. Promotion of regenerative phenotypic responses in SCs and other non-neuronal cells that can augment the regenerative capacity of multiple biomaterials is considered along with innovations and technologies for traumatic injury.http://www.sciencedirect.com/science/article/pii/S0171933522000802Schwann cellBiomaterialNerve RepairMicroenvironmentExtracellular matrix |
| spellingShingle | Corinne S. Smith Jacob A. Orkwis Andrew E. Bryan Zhenyuan Xu Greg M. Harris The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity European Journal of Cell Biology Schwann cell Biomaterial Nerve Repair Microenvironment Extracellular matrix |
| title | The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity |
| title_full | The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity |
| title_fullStr | The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity |
| title_full_unstemmed | The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity |
| title_short | The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity |
| title_sort | impact of physical biochemical and electrical signaling on schwann cell plasticity |
| topic | Schwann cell Biomaterial Nerve Repair Microenvironment Extracellular matrix |
| url | http://www.sciencedirect.com/science/article/pii/S0171933522000802 |
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