<i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis
Atopic Dermatitis (AD) is a chronically relapsing skin condition characterized by dry, itchy, and inflamed skin where sufferers can frequently be subject to infections. Probiotics are known to be potent immune-modulators, and live <i>Lactobacillus reuteri</i> DSM 17938 has shown to be an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/7/1026 |
| _version_ | 1797562679465869312 |
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| author | Éile Butler Christoffer Lundqvist Jakob Axelsson |
| author_facet | Éile Butler Christoffer Lundqvist Jakob Axelsson |
| author_sort | Éile Butler |
| collection | DOAJ |
| description | Atopic Dermatitis (AD) is a chronically relapsing skin condition characterized by dry, itchy, and inflamed skin where sufferers can frequently be subject to infections. Probiotics are known to be potent immune-modulators, and live <i>Lactobacillus reuteri</i> DSM 17938 has shown to be anti-inflammatory but also to possess antimicrobial and barrier function properties. This study aimed to investigate and compare two investigational ointment products (topical probiotic and control) for cutaneous acceptability, safety, and efficacy under normal conditions of use, in adult subjects with atopic dermatitis. The products were applied twice daily for 8 weeks, and cutaneous acceptability, SCORAD index, local SCORAD, and adverse events were evaluated after 4 and 8 weeks of treatment. At the end of the observations, it was demonstrated that both the probiotic-containing and probiotic-free ointments were both cutaneously acceptable and safe. It importantly showed a statistically and clinically significant improvement of the SCORAD index and local SCORAD in adult subjects with AD after 4 and 8 weeks of continuous use. In conclusion, we show evidence that the probiotic product, containing live <i>L. reuteri</i> DSM 17938 as an extra ingredient, is safe and promising as a novel topical cosmetic ointment and with further testing could be a standard topical product for the management of atopic dermatitis or other disorders associated with the skin. |
| first_indexed | 2024-03-10T18:32:24Z |
| format | Article |
| id | doaj.art-335a7a56283349b6bfacc2d6da294121 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:32:24Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-335a7a56283349b6bfacc2d6da2941212023-11-20T06:30:45ZengMDPI AGMicroorganisms2076-26072020-07-0187102610.3390/microorganisms8071026<i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic DermatitisÉile Butler0Christoffer Lundqvist1Jakob Axelsson2BioGaia AB, Mobilvägen 10, 223 62 Lund, SwedenBioGaia AB, Mobilvägen 10, 223 62 Lund, SwedenBioGaia AB, Mobilvägen 10, 223 62 Lund, SwedenAtopic Dermatitis (AD) is a chronically relapsing skin condition characterized by dry, itchy, and inflamed skin where sufferers can frequently be subject to infections. Probiotics are known to be potent immune-modulators, and live <i>Lactobacillus reuteri</i> DSM 17938 has shown to be anti-inflammatory but also to possess antimicrobial and barrier function properties. This study aimed to investigate and compare two investigational ointment products (topical probiotic and control) for cutaneous acceptability, safety, and efficacy under normal conditions of use, in adult subjects with atopic dermatitis. The products were applied twice daily for 8 weeks, and cutaneous acceptability, SCORAD index, local SCORAD, and adverse events were evaluated after 4 and 8 weeks of treatment. At the end of the observations, it was demonstrated that both the probiotic-containing and probiotic-free ointments were both cutaneously acceptable and safe. It importantly showed a statistically and clinically significant improvement of the SCORAD index and local SCORAD in adult subjects with AD after 4 and 8 weeks of continuous use. In conclusion, we show evidence that the probiotic product, containing live <i>L. reuteri</i> DSM 17938 as an extra ingredient, is safe and promising as a novel topical cosmetic ointment and with further testing could be a standard topical product for the management of atopic dermatitis or other disorders associated with the skin.https://www.mdpi.com/2076-2607/8/7/1026<i>Lactobacillus reuteri</i> DSM 17938cosmeticprobioticsatopic dermatitisadultsin-use test |
| spellingShingle | Éile Butler Christoffer Lundqvist Jakob Axelsson <i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis Microorganisms <i>Lactobacillus reuteri</i> DSM 17938 cosmetic probiotics atopic dermatitis adults in-use test |
| title | <i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis |
| title_full | <i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis |
| title_fullStr | <i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis |
| title_full_unstemmed | <i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis |
| title_short | <i>Lactobacillus reuteri</i> DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis |
| title_sort | i lactobacillus reuteri i dsm 17938 as a novel topical cosmetic ingredient a proof of concept clinical study in adults with atopic dermatitis |
| topic | <i>Lactobacillus reuteri</i> DSM 17938 cosmetic probiotics atopic dermatitis adults in-use test |
| url | https://www.mdpi.com/2076-2607/8/7/1026 |
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