Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort study
Abstract Background Higher D‐dimer is a risk factor for cardiovascular diseases and venous thromboembolism. In the general population, D‐dimer and other thrombo‐inflammatory biomarkers are higher among Black individuals, who also have higher risk of these conditions compared to White people. Objecti...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12632 |
| _version_ | 1797707180731793408 |
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| author | Debora Kamin Mukaz Mansour Gergi Insu Koh Neil A. Zakai Suzanne E. Judd Michelle Sholzberg Lisa Baumann Kreuziger Kalev Freeman Christos Colovos Nels C. Olson Mary Cushman |
| author_facet | Debora Kamin Mukaz Mansour Gergi Insu Koh Neil A. Zakai Suzanne E. Judd Michelle Sholzberg Lisa Baumann Kreuziger Kalev Freeman Christos Colovos Nels C. Olson Mary Cushman |
| author_sort | Debora Kamin Mukaz |
| collection | DOAJ |
| description | Abstract Background Higher D‐dimer is a risk factor for cardiovascular diseases and venous thromboembolism. In the general population, D‐dimer and other thrombo‐inflammatory biomarkers are higher among Black individuals, who also have higher risk of these conditions compared to White people. Objective To assess whether Black individuals have an exaggerated correlation between D‐dimer and thrombo‐inflammatory biomarkers characteristic of cardiovascular diseases. Methods Linear regression was used to assess correlations of 11 thrombo‐inflammatory biomarkers with D‐dimer in a cross‐sectional study of 1068 participants of the biracial Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Results Adverse levels of most biomarkers, especially fibrinogen, factor VIII, C‐reactive protein, N‐terminal pro‐B‐type natriuretic peptide, and interleukin (IL)‐6, were associated with higher D‐dimer. Several associations with D‐dimer differed significantly by race. For example, the association of factor VIII with D‐dimer was more than twice as large in Black compared to White participants. Specifically, D‐dimer was 26% higher per standard deviation (SD) higher factor VIII in Black adults and was only 11% higher per SD higher factor VIII in White adults. In Black but not White adults, higher IL‐10 and soluble CD14 were associated with higher D‐dimer. Conclusions Findings suggest that D‐dimer might relate to Black/White differences in cardiovascular diseases and venous thromboembolism because it is a marker of amplified thrombo‐inflammatory response in Black people. Better understanding of contributors to higher D‐dimer in the general population is needed. |
| first_indexed | 2024-03-12T06:03:32Z |
| format | Article |
| id | doaj.art-335cfbb4232f4983ad0fc1cefe93bb50 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T06:03:32Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-335cfbb4232f4983ad0fc1cefe93bb502023-09-03T03:52:09ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792021-12-0158n/an/a10.1002/rth2.12632Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort studyDebora Kamin Mukaz0Mansour Gergi1Insu Koh2Neil A. Zakai3Suzanne E. Judd4Michelle Sholzberg5Lisa Baumann Kreuziger6Kalev Freeman7Christos Colovos8Nels C. Olson9Mary Cushman10Department of Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USADepartment of Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USADepartment of Pathology and Laboratory Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USADepartment of Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USADepartment of Biostatistics University of Alabama at Birmingham Birmingham Alabama USADepartment of Medicine University of Toronto Toronto Ontario CanadaBlood Research Institute Versiti, Milwaukee Wisconsin USADepartment of Surgery Larner College of Medicine at the University of Vermont Burlington Vermont USADepartment of Surgery Larner College of Medicine at the University of Vermont Burlington Vermont USADepartment of Pathology and Laboratory Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USADepartment of Medicine Larner College of Medicine at the University of Vermont Burlington Vermont USAAbstract Background Higher D‐dimer is a risk factor for cardiovascular diseases and venous thromboembolism. In the general population, D‐dimer and other thrombo‐inflammatory biomarkers are higher among Black individuals, who also have higher risk of these conditions compared to White people. Objective To assess whether Black individuals have an exaggerated correlation between D‐dimer and thrombo‐inflammatory biomarkers characteristic of cardiovascular diseases. Methods Linear regression was used to assess correlations of 11 thrombo‐inflammatory biomarkers with D‐dimer in a cross‐sectional study of 1068 participants of the biracial Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Results Adverse levels of most biomarkers, especially fibrinogen, factor VIII, C‐reactive protein, N‐terminal pro‐B‐type natriuretic peptide, and interleukin (IL)‐6, were associated with higher D‐dimer. Several associations with D‐dimer differed significantly by race. For example, the association of factor VIII with D‐dimer was more than twice as large in Black compared to White participants. Specifically, D‐dimer was 26% higher per standard deviation (SD) higher factor VIII in Black adults and was only 11% higher per SD higher factor VIII in White adults. In Black but not White adults, higher IL‐10 and soluble CD14 were associated with higher D‐dimer. Conclusions Findings suggest that D‐dimer might relate to Black/White differences in cardiovascular diseases and venous thromboembolism because it is a marker of amplified thrombo‐inflammatory response in Black people. Better understanding of contributors to higher D‐dimer in the general population is needed.https://doi.org/10.1002/rth2.12632biomarkerscardiovascular diseasesD‐dimerracethrombo‐inflammation |
| spellingShingle | Debora Kamin Mukaz Mansour Gergi Insu Koh Neil A. Zakai Suzanne E. Judd Michelle Sholzberg Lisa Baumann Kreuziger Kalev Freeman Christos Colovos Nels C. Olson Mary Cushman Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort study Research and Practice in Thrombosis and Haemostasis biomarkers cardiovascular diseases D‐dimer race thrombo‐inflammation |
| title | Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort study |
| title_full | Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort study |
| title_fullStr | Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort study |
| title_full_unstemmed | Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort study |
| title_short | Thrombo‐inflammatory biomarkers and D‐dimer in a biracial cohort study |
| title_sort | thrombo inflammatory biomarkers and d dimer in a biracial cohort study |
| topic | biomarkers cardiovascular diseases D‐dimer race thrombo‐inflammation |
| url | https://doi.org/10.1002/rth2.12632 |
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