Effects of the neonatal intensive care environment on circadian health and development of preterm infants
The circadian system in mammals ensures adaptation to the light-dark cycle on Earth and imposes 24-h rhythmicity on metabolic, physiological and behavioral processes. The central circadian pacemaker is located in the brain and is entrained by environmental signals called Zeitgebers. From here, neura...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1243162/full |
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| author | D. Van Gilst A. V. Puchkina J. A. Roelants L. Kervezee J. Dudink I. K. M. Reiss G. T. J. Van Der Horst M. J. Vermeulen I. Chaves |
| author_facet | D. Van Gilst A. V. Puchkina J. A. Roelants L. Kervezee J. Dudink I. K. M. Reiss G. T. J. Van Der Horst M. J. Vermeulen I. Chaves |
| author_sort | D. Van Gilst |
| collection | DOAJ |
| description | The circadian system in mammals ensures adaptation to the light-dark cycle on Earth and imposes 24-h rhythmicity on metabolic, physiological and behavioral processes. The central circadian pacemaker is located in the brain and is entrained by environmental signals called Zeitgebers. From here, neural, humoral and systemic signals drive rhythms in peripheral clocks in nearly every mammalian tissue. During pregnancy, disruption of the complex interplay between the mother’s rhythmic signals and the fetal developing circadian system can lead to long-term health consequences in the offspring. When an infant is born very preterm, it loses the temporal signals received from the mother prematurely and becomes totally dependent on 24/7 care in the Neonatal Intensive Care Unit (NICU), where day/night rhythmicity is usually blurred. In this literature review, we provide an overview of the fetal and neonatal development of the circadian system, and short-term consequences of disruption of this process as occurs in the NICU environment. Moreover, we provide a theoretical and molecular framework of how this disruption could lead to later-life disease. Finally, we discuss studies that aim to improve health outcomes after preterm birth by studying the effects of enhancing rhythmicity in light and noise exposure. |
| first_indexed | 2024-03-12T11:49:25Z |
| format | Article |
| id | doaj.art-335d0db2a466449caa5a785d5085cee4 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-12T11:49:25Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-335d0db2a466449caa5a785d5085cee42023-08-31T10:19:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-08-011410.3389/fphys.2023.12431621243162Effects of the neonatal intensive care environment on circadian health and development of preterm infantsD. Van Gilst0A. V. Puchkina1J. A. Roelants2L. Kervezee3J. Dudink4I. K. M. Reiss5G. T. J. Van Der Horst6M. J. Vermeulen7I. Chaves8Department of Molecular Genetics, Erasmus University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Developmental Biology, Erasmus University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus University Medical Center Rotterdam-Sophia Children’s Hospital, Rotterdam, NetherlandsDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Neonatology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus University Medical Center Rotterdam-Sophia Children’s Hospital, Rotterdam, NetherlandsDepartment of Molecular Genetics, Erasmus University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus University Medical Center Rotterdam-Sophia Children’s Hospital, Rotterdam, NetherlandsDepartment of Molecular Genetics, Erasmus University Medical Center Rotterdam, Rotterdam, NetherlandsThe circadian system in mammals ensures adaptation to the light-dark cycle on Earth and imposes 24-h rhythmicity on metabolic, physiological and behavioral processes. The central circadian pacemaker is located in the brain and is entrained by environmental signals called Zeitgebers. From here, neural, humoral and systemic signals drive rhythms in peripheral clocks in nearly every mammalian tissue. During pregnancy, disruption of the complex interplay between the mother’s rhythmic signals and the fetal developing circadian system can lead to long-term health consequences in the offspring. When an infant is born very preterm, it loses the temporal signals received from the mother prematurely and becomes totally dependent on 24/7 care in the Neonatal Intensive Care Unit (NICU), where day/night rhythmicity is usually blurred. In this literature review, we provide an overview of the fetal and neonatal development of the circadian system, and short-term consequences of disruption of this process as occurs in the NICU environment. Moreover, we provide a theoretical and molecular framework of how this disruption could lead to later-life disease. Finally, we discuss studies that aim to improve health outcomes after preterm birth by studying the effects of enhancing rhythmicity in light and noise exposure.https://www.frontiersin.org/articles/10.3389/fphys.2023.1243162/fullcircadian rhythmdevelopmentNICUchrono-nutritionhealthchronobiology |
| spellingShingle | D. Van Gilst A. V. Puchkina J. A. Roelants L. Kervezee J. Dudink I. K. M. Reiss G. T. J. Van Der Horst M. J. Vermeulen I. Chaves Effects of the neonatal intensive care environment on circadian health and development of preterm infants Frontiers in Physiology circadian rhythm development NICU chrono-nutrition health chronobiology |
| title | Effects of the neonatal intensive care environment on circadian health and development of preterm infants |
| title_full | Effects of the neonatal intensive care environment on circadian health and development of preterm infants |
| title_fullStr | Effects of the neonatal intensive care environment on circadian health and development of preterm infants |
| title_full_unstemmed | Effects of the neonatal intensive care environment on circadian health and development of preterm infants |
| title_short | Effects of the neonatal intensive care environment on circadian health and development of preterm infants |
| title_sort | effects of the neonatal intensive care environment on circadian health and development of preterm infants |
| topic | circadian rhythm development NICU chrono-nutrition health chronobiology |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1243162/full |
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