Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study
Abstract Aims Hyponatremia is a common electrolyte disorder. The severe hyponatremia has a mortality rate of 4%–40%. Psychiatric patients are likely to develop the condition because of polydipsia or the adverse effects of antipsychotics. We investigated the characteristics of patients with and witho...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
|
| Series: | PCN Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pcn5.77 |
| _version_ | 1797853307789639680 |
|---|---|
| author | Eriko Makino Takahide Hashimoto Akahito Sako Hideki Nanasawa Tetsuro Enomoto Tatsuro Hayakawa Hidetaka Hamasaki Hidekatsu Yanai |
| author_facet | Eriko Makino Takahide Hashimoto Akahito Sako Hideki Nanasawa Tetsuro Enomoto Tatsuro Hayakawa Hidetaka Hamasaki Hidekatsu Yanai |
| author_sort | Eriko Makino |
| collection | DOAJ |
| description | Abstract Aims Hyponatremia is a common electrolyte disorder. The severe hyponatremia has a mortality rate of 4%–40%. Psychiatric patients are likely to develop the condition because of polydipsia or the adverse effects of antipsychotics. We investigated the characteristics of patients with and without psychiatric diseases who developed severe hyponatremia. Materials and Methods We retrospectively investigated cases admitted to our hospital (all departments) between October 2012 and November 2015 with a serum sodium concentration of ≤125 mmol/l on admission. We compared patient characteristics, etiology, and clinical course between psychiatric and nonpsychiatric patients. Results In total, 123 cases (62 female) were analyzed. Psychiatric disorders were present in 69 cases (56%), including schizophrenia (n = 19), anorexia (n = 16), mood disorders (n = 14), and organic mental disorders (n = 9). The mean patient age was 63 years. The mean serum sodium concentration on admission was 119 mmol/l, and the main causes of hyponatremia were polydipsia (20%), insufficient sodium intake (18%), and syndrome of inappropriate antidiuretic hormone secretion (16%). Compared with the nonpsychiatric group, the psychiatric group was significantly younger (55 vs. 74 years), was more likely to have polydipsia (30% vs. 6%), and had a lower in‐hospital mortality (0% vs. 17%). Conclusions Our study found differences in the clinical picture between psychiatric and nonpsychiatric patients with severe hyponatremia. Clinicians need to monitor serum sodium because the symptoms of hyponatremia can mimic those of psychiatric diseases. |
| first_indexed | 2024-04-09T19:48:31Z |
| format | Article |
| id | doaj.art-335e9bfcf31e4f8f8af1de69c06a5eea |
| institution | Directory Open Access Journal |
| issn | 2769-2558 |
| language | English |
| last_indexed | 2024-04-09T19:48:31Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj.art-335e9bfcf31e4f8f8af1de69c06a5eea2023-04-03T11:55:56ZengWileyPCN Reports2769-25582023-03-0121n/an/a10.1002/pcn5.77Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective studyEriko Makino0Takahide Hashimoto1Akahito Sako2Hideki Nanasawa3Tetsuro Enomoto4Tatsuro Hayakawa5Hidetaka Hamasaki6Hidekatsu Yanai7Department of Internal Medicine, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanDepartment of Internal Medicine, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanDepartment of Internal Medicine, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanDepartment of Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanDepartment of Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanDepartment of Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanDepartment of Internal Medicine, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanDepartment of Internal Medicine, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba JapanAbstract Aims Hyponatremia is a common electrolyte disorder. The severe hyponatremia has a mortality rate of 4%–40%. Psychiatric patients are likely to develop the condition because of polydipsia or the adverse effects of antipsychotics. We investigated the characteristics of patients with and without psychiatric diseases who developed severe hyponatremia. Materials and Methods We retrospectively investigated cases admitted to our hospital (all departments) between October 2012 and November 2015 with a serum sodium concentration of ≤125 mmol/l on admission. We compared patient characteristics, etiology, and clinical course between psychiatric and nonpsychiatric patients. Results In total, 123 cases (62 female) were analyzed. Psychiatric disorders were present in 69 cases (56%), including schizophrenia (n = 19), anorexia (n = 16), mood disorders (n = 14), and organic mental disorders (n = 9). The mean patient age was 63 years. The mean serum sodium concentration on admission was 119 mmol/l, and the main causes of hyponatremia were polydipsia (20%), insufficient sodium intake (18%), and syndrome of inappropriate antidiuretic hormone secretion (16%). Compared with the nonpsychiatric group, the psychiatric group was significantly younger (55 vs. 74 years), was more likely to have polydipsia (30% vs. 6%), and had a lower in‐hospital mortality (0% vs. 17%). Conclusions Our study found differences in the clinical picture between psychiatric and nonpsychiatric patients with severe hyponatremia. Clinicians need to monitor serum sodium because the symptoms of hyponatremia can mimic those of psychiatric diseases.https://doi.org/10.1002/pcn5.77antipsychoticspolydipsiaschizophreniaSIADH |
| spellingShingle | Eriko Makino Takahide Hashimoto Akahito Sako Hideki Nanasawa Tetsuro Enomoto Tatsuro Hayakawa Hidetaka Hamasaki Hidekatsu Yanai Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study PCN Reports antipsychotics polydipsia schizophrenia SIADH |
| title | Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study |
| title_full | Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study |
| title_fullStr | Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study |
| title_full_unstemmed | Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study |
| title_short | Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single‐center retrospective study |
| title_sort | comparison of severe hyponatremia in patients with and without psychiatric diseases a single center retrospective study |
| topic | antipsychotics polydipsia schizophrenia SIADH |
| url | https://doi.org/10.1002/pcn5.77 |
| work_keys_str_mv | AT erikomakino comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy AT takahidehashimoto comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy AT akahitosako comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy AT hidekinanasawa comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy AT tetsuroenomoto comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy AT tatsurohayakawa comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy AT hidetakahamasaki comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy AT hidekatsuyanai comparisonofseverehyponatremiainpatientswithandwithoutpsychiatricdiseasesasinglecenterretrospectivestudy |