The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis
Peritoneal fibrosis is an important cause of peritoneal dialysis (PD) discontinuation worldwide and is associated with high morbidity and mortality rate. Although the era of metagenomics has provided new insights into the interactions between the gut microbiota and fibrosis in various organs and tis...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Kidney Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059523000559 |
| _version_ | 1797825584611459072 |
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| author | Natalia Stepanova |
| author_facet | Natalia Stepanova |
| author_sort | Natalia Stepanova |
| collection | DOAJ |
| description | Peritoneal fibrosis is an important cause of peritoneal dialysis (PD) discontinuation worldwide and is associated with high morbidity and mortality rate. Although the era of metagenomics has provided new insights into the interactions between the gut microbiota and fibrosis in various organs and tissues, its role in peritoneal fibrosis has rarely been discussed. This review provides a scientific rationale and points out the potential role of gut microbiota in peritoneal fibrosis. In addition, the interaction between the gut, circulatory, and peritoneal microbiota is highlighted, with an emphasis on the relationship to PD outcomes. More research is needed to elucidate the mechanisms underlying the role of gut microbiota in peritoneal fibrosis and potentially unveil new target options for the management of PD technique failure. |
| first_indexed | 2024-03-13T10:56:07Z |
| format | Article |
| id | doaj.art-335f36f500664a2a9d52a1a17beb932d |
| institution | Directory Open Access Journal |
| issn | 2590-0595 |
| language | English |
| last_indexed | 2024-03-13T10:56:07Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj.art-335f36f500664a2a9d52a1a17beb932d2023-05-17T04:23:12ZengElsevierKidney Medicine2590-05952023-06-0156100645The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal FibrosisNatalia Stepanova0Address for Correspondence: Natalia Stepanova, MD, DSc, Prof., Department of Nephrology and Dialysis, State Institution “Institute of Nephrology of the National Academy of Medical Sciences of Ukraine”, 17 V Degtyarivska, Kyiv 04050, Ukraine.; Department of Nephrology and Dialysis, State Institution “Institute of Nephrology of the National Academy of Medical Sciences of Ukraine”, Kyiv, UkrainePeritoneal fibrosis is an important cause of peritoneal dialysis (PD) discontinuation worldwide and is associated with high morbidity and mortality rate. Although the era of metagenomics has provided new insights into the interactions between the gut microbiota and fibrosis in various organs and tissues, its role in peritoneal fibrosis has rarely been discussed. This review provides a scientific rationale and points out the potential role of gut microbiota in peritoneal fibrosis. In addition, the interaction between the gut, circulatory, and peritoneal microbiota is highlighted, with an emphasis on the relationship to PD outcomes. More research is needed to elucidate the mechanisms underlying the role of gut microbiota in peritoneal fibrosis and potentially unveil new target options for the management of PD technique failure.http://www.sciencedirect.com/science/article/pii/S2590059523000559Peritoneal dialysisperitoneal fibrosismicrobiotaclinical outcomes |
| spellingShingle | Natalia Stepanova The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis Kidney Medicine Peritoneal dialysis peritoneal fibrosis microbiota clinical outcomes |
| title | The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis |
| title_full | The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis |
| title_fullStr | The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis |
| title_full_unstemmed | The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis |
| title_short | The Gut-Peritoneum Axis in Peritoneal Dialysis and Peritoneal Fibrosis |
| title_sort | gut peritoneum axis in peritoneal dialysis and peritoneal fibrosis |
| topic | Peritoneal dialysis peritoneal fibrosis microbiota clinical outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S2590059523000559 |
| work_keys_str_mv | AT nataliastepanova thegutperitoneumaxisinperitonealdialysisandperitonealfibrosis AT nataliastepanova gutperitoneumaxisinperitonealdialysisandperitonealfibrosis |