Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studies
Objective: To examine the relationship between long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence and progression of radiographic hip osteoarthritis (RHOA), as well as the degeneration of individual radiographic features. Methods: We analyzed data from the Osteoarthrit...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913123000948 |
| _version_ | 1797292875768135680 |
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| author | Zubeyir Salis |
| author_facet | Zubeyir Salis |
| author_sort | Zubeyir Salis |
| collection | DOAJ |
| description | Objective: To examine the relationship between long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence and progression of radiographic hip osteoarthritis (RHOA), as well as the degeneration of individual radiographic features. Methods: We analyzed data from the Osteoarthritis Initiative (OAI) and the Cohort Hip and Cohort Knee (CHECK) study. Our exposure was the number of years of NSAID use over a 4-to-5-year follow-up period. Our outcomes were the incidence and progression of RHOA over a 4-to-5-year follow-up as assessed using a modified Croft grade in OAI and the Kellgren-Lawrence (K/L) grade in CHECK. The incidence of RHOA was defined as having RHOA (grade ≥2) at follow-up and investigated in “incidence cohorts” of hips without RHOA at baseline (grade <2). The progression of RHOA was defined as an increase of ≥1 grade at follow-up from baseline and investigated in “progression cohorts” of hips with RHOA at baseline (grade ≥2). Additionally, we assessed the degeneration of nine specific radiographic features, such as joint space narrowing and osteophytes, defined by a grade increase of ≥1 at follow-up from baseline, in all cohorts. Results: In the incidence cohorts, there were 5153 hips in OAI and 1011 in CHECK; in the progression cohorts, there were 285 and 106 hips, respectively. There was no association between NSAID use and the outcomes investigated. Conclusion: Over 4-to-5 years, long-term NSAID use showed no association with the incidence or progression of RHOA, or with the degeneration of individual radiographic features. |
| first_indexed | 2024-03-07T20:03:54Z |
| format | Article |
| id | doaj.art-335f7a6a2fd146eaaa6979d53be3e35d |
| institution | Directory Open Access Journal |
| issn | 2665-9131 |
| language | English |
| last_indexed | 2024-03-07T20:03:54Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj.art-335f7a6a2fd146eaaa6979d53be3e35d2024-02-28T05:14:05ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-03-0161100427Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studiesZubeyir Salis0Division of Rheumatology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland; The University of Western Australia, School of Human Sciences, Perth, WA, Australia; The University of New South Wales, Centre for Big Data Research in Health, Kensington, NSW, Australia; HUG Av. de Beau-Séjour 26, 1206, Genève, Switzerland.Objective: To examine the relationship between long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) and the incidence and progression of radiographic hip osteoarthritis (RHOA), as well as the degeneration of individual radiographic features. Methods: We analyzed data from the Osteoarthritis Initiative (OAI) and the Cohort Hip and Cohort Knee (CHECK) study. Our exposure was the number of years of NSAID use over a 4-to-5-year follow-up period. Our outcomes were the incidence and progression of RHOA over a 4-to-5-year follow-up as assessed using a modified Croft grade in OAI and the Kellgren-Lawrence (K/L) grade in CHECK. The incidence of RHOA was defined as having RHOA (grade ≥2) at follow-up and investigated in “incidence cohorts” of hips without RHOA at baseline (grade <2). The progression of RHOA was defined as an increase of ≥1 grade at follow-up from baseline and investigated in “progression cohorts” of hips with RHOA at baseline (grade ≥2). Additionally, we assessed the degeneration of nine specific radiographic features, such as joint space narrowing and osteophytes, defined by a grade increase of ≥1 at follow-up from baseline, in all cohorts. Results: In the incidence cohorts, there were 5153 hips in OAI and 1011 in CHECK; in the progression cohorts, there were 285 and 106 hips, respectively. There was no association between NSAID use and the outcomes investigated. Conclusion: Over 4-to-5 years, long-term NSAID use showed no association with the incidence or progression of RHOA, or with the degeneration of individual radiographic features.http://www.sciencedirect.com/science/article/pii/S2665913123000948OsteoarthritisHipNon-steroidal anti-inflammatory drugsNSAIDsRadiographic hip osteoarthritis |
| spellingShingle | Zubeyir Salis Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studies Osteoarthritis and Cartilage Open Osteoarthritis Hip Non-steroidal anti-inflammatory drugs NSAIDs Radiographic hip osteoarthritis |
| title | Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studies |
| title_full | Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studies |
| title_fullStr | Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studies |
| title_full_unstemmed | Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studies |
| title_short | Investigation of the association of long-term NSAID use with radiographic hip osteoarthritis over four to five years: Data from the OAI and CHECK studies |
| title_sort | investigation of the association of long term nsaid use with radiographic hip osteoarthritis over four to five years data from the oai and check studies |
| topic | Osteoarthritis Hip Non-steroidal anti-inflammatory drugs NSAIDs Radiographic hip osteoarthritis |
| url | http://www.sciencedirect.com/science/article/pii/S2665913123000948 |
| work_keys_str_mv | AT zubeyirsalis investigationoftheassociationoflongtermnsaidusewithradiographichiposteoarthritisoverfourtofiveyearsdatafromtheoaiandcheckstudies |