The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA

The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA

Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. Besides functioning as a calcium- and lipidbinding protein, AnxA2 also acts as an mRNA-binding protein, for instance, by interacting with regulatory regions of specific c...

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Bibliographic Details
Main Authors: Ann Kari Grindheim, Sudarshan S. Patil, Canan G. Nebigil, Laurent Désaubry, Anni Vedeler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Annexin A2
FL3
translation
initiation complex
eIF4F
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1094941/full

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